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    Tacc3 transforming, acidic coiled-coil containing protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 21335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tacc3provided by MGI
    Official Full Name
    transforming, acidic coiled-coil containing protein 3provided by MGI
    Primary source
    MGI:MGI:1341163
    See related
    Ensembl:ENSMUSG00000037313 AllianceGenome:MGI:1341163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aint; Eric1
    Summary
    Enables protein domain specific binding activity. Acts upstream of or within several processes, including astral microtubule organization; cytoplasmic sequestering of transcription factor; and nervous system development. Located in centrosome and cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 34.6), liver E14 (RPKM 25.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tacc3 in Genome Data Viewer
    Location:
    5 B2; 5 17.83 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33814808..33836331)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33658128..33672203)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene predicted gene 9903 Neighboring gene STARR-positive B cell enhancer ABC_E6318 Neighboring gene stem-loop binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34000710-34000897 Neighboring gene predicted gene 10459 Neighboring gene transmembrane protein 129 Neighboring gene STARR-seq mESC enhancer starr_12827 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene ribosomal protein S29 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aint/Tacc3 is highly expressed in proliferating mouse tissues during development, spermatogenesis, and oogenesis. Aitola M, et al. J Histochem Cytochem, 2003 Apr. PMID 12642624
    2. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. Garriga-Canut M, et al. J Biol Chem, 2004 May 28. PMID 15037632
    3. Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Bargo S, et al. Biochem Biophys Res Commun, 2010 Oct 1. PMID 20804727, Free PMC Article
    4. Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding. Hood FE, et al. J Cell Biol, 2013 Aug 5. PMID 23918938, Free PMC Article
    5. Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice. Simerly C, et al. Sci Rep, 2024 Feb 27. PMID 38413710, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
      Title: Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
    2. Aurora kinase A is essential for meiosis in mouse oocytes.
      Title: Aurora kinase A is essential for meiosis in mouse oocytes.
    3. Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation.
      Title: Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation.
    4. Tacc3 is required for the proper mitosis of Apc-deficient ISCs, and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival.
      Title: Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.
    5. Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.
      Title: The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
    6. The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
      Title: Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
    7. DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
      Title: DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
    8. results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
      Title: Disruption of Tacc3 function leads to in vivo tumor regression.
    9. Tacc3 is a negative regulator of the Notch signaling pathway.
      Title: Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
    10. in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
      Title: TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoplasmic sequestering of transcription factor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization involved in mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 3
    Names
    ARNT-interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040435.4 → NP_001035525.1  transforming acidic coiled-coil-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001035525.1

      Status: VALIDATED

      Source sequence(s)
      AC162898
      Consensus CDS
      CCDS39065.1
      UniProtKB/TrEMBL
      Q6NV52, Q9JIQ5
      Related
      ENSMUSP00000110069.4, ENSMUST00000114426.10
      Conserved Domains (2) summary
      pfam05010
      Location:428 → 624
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl03075
      Location:426 → 580
      GrpE; nucleotide exchange factor GrpE

    2. NM_001310541.2 → NP_001297470.1  transforming acidic coiled-coil-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001297470.1

      Status: VALIDATED

      Source sequence(s)
      AC162898
      Consensus CDS
      CCDS80258.1
      UniProtKB/TrEMBL
      Q99LH8, Q9JIQ5
      Related
      ENSMUSP00000074394.7, ENSMUST00000074849.13
      Conserved Domains (2) summary
      PRK10811
      Location:144 → 294
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:435 → 631
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. NM_001405350.1 → NP_001392279.1  transforming acidic coiled-coil-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    4. NM_001405351.1 → NP_001392280.1  transforming acidic coiled-coil-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    5. NM_001405352.1 → NP_001392281.1  transforming acidic coiled-coil-containing protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    6. NM_001405353.1 → NP_001392282.1  transforming acidic coiled-coil-containing protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    7. NM_001405354.1 → NP_001392283.1  transforming acidic coiled-coil-containing protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    8. NM_001405355.1 → NP_001392284.1  transforming acidic coiled-coil-containing protein 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC162898

    9. NM_001405356.1 → NP_001392285.1  transforming acidic coiled-coil-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q6NV52, Q9JIQ5
      Related
      ENSMUSP00000078491.5, ENSMUST00000079534.11

    10. NM_001405357.1 → NP_001392286.1  transforming acidic coiled-coil-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q6NV52, Q9JIQ5

    11. NM_001405358.1 → NP_001392287.1  transforming acidic coiled-coil-containing protein 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    12. NM_001405360.1 → NP_001392289.1  transforming acidic coiled-coil-containing protein 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      Q9JIQ5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      33814808..33836331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254350.2 → XP_030110210.1  transforming acidic coiled-coil-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      Q9JIQ5
      Conserved Domains (2) summary
      PRK10811
      Location:144 → 294
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:428 → 569
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    2. XM_030254352.2 → XP_030110212.1  transforming acidic coiled-coil-containing protein 3 isoform X9

      Conserved Domains (2) summary
      PRK10811
      Location:71 → 221
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:355 → 496
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. XM_030254349.2 → XP_030110209.1  transforming acidic coiled-coil-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      Q9JIQ5
      Conserved Domains (3) summary
      PRK10263
      Location:23 → 274
      PRK10263; DNA translocase FtsK; Provisional
      PRK10811
      Location:160 → 310
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:444 → 626
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    4. XM_006503835.5 → XP_006503898.1  transforming acidic coiled-coil-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      Q9JIQ5
      Conserved Domains (2) summary
      PRK10811
      Location:71 → 221
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:362 → 558
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    5. XM_011240716.4 → XP_011239018.1  transforming acidic coiled-coil-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      Q9JIQ5
      Conserved Domains (3) summary
      PRK10263
      Location:23 → 274
      PRK10263; DNA translocase FtsK; Provisional
      PRK10811
      Location:160 → 310
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:451 → 592
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    6. XM_011240715.1 → XP_011239017.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      Q9JIQ5
      Conserved Domains (3) summary
      PRK10263
      Location:23 → 274
      PRK10263; DNA translocase FtsK; Provisional
      PRK10811
      Location:160 → 310
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:444 → 640
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    7. XM_036164983.1 → XP_036020876.1  transforming acidic coiled-coil-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      Q9JIQ5
      Conserved Domains (3) summary
      PRK10263
      Location:23 → 274
      PRK10263; DNA translocase FtsK; Provisional
      PRK10811
      Location:160 → 310
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:444 → 583
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    8. XM_006503832.4 → XP_006503895.1  transforming acidic coiled-coil-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006503895.1

      UniProtKB/TrEMBL
      Q99LH8, Q9JIQ5
      Conserved Domains (2) summary
      PRK10811
      Location:144 → 294
      rne; ribonuclease E; Reviewed
      pfam05010
      Location:435 → 631
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    RNA

    1. XR_868281.4 RNA Sequence

    2. XR_003955613.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011524.3: Suppressed sequence

      Description
      NM_011524.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJ11.1 GenPept UniProtKB/Swiss-Prot:Q9JJ11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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