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    mlt-11 Papilin [ Caenorhabditis elegans ]

    Gene ID: 180352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlt-11
    Official Full Name
    Papilin
    Primary source
    WormBase:WBGene00012186
    Locus tag
    CELE_W01F3.3
    See related
    AllianceGenome:WB:WBGene00012186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlt-11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (20667205..20678537)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Menorin Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans mapping locus rol-9 is encoded by a gain-of-function mutation in mlt-11. Rich MS, et al. MicroPubl Biol, 2022. PMID 35005481, Free PMC Article
    2. Experimental considerations for study of C. elegans lysosomal proteins. Clancy JC, et al. G3 (Bethesda), 2023 Apr 11. PMID 36748711, Free PMC Article
    3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
    4. Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson's disease. Gaeta AL, et al. iScience, 2023 Jun 16. PMID 37260751, Free PMC Article
    5. NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function. Johnson LC, et al. Development, 2023 May 15. PMID 37129010, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Papilin
    NP_001256938.1
    • Confirmed by transcript evidence
    NP_001256939.1
    • Confirmed by transcript evidence
    NP_001256940.1
    • Confirmed by transcript evidence
    NP_001256941.1
    • Confirmed by transcript evidence
    NP_001256942.1
    • Confirmed by transcript evidence
    NP_001256943.1
    • Confirmed by transcript evidence
    NP_001256944.1
    • Confirmed by transcript evidence
    NP_001256945.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20667205..20678537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270015.4 → NP_001256944.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G335
      Conserved Domains (5) summary
      cd00109
      Location:514 → 566
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00191
      Location:140 → 188
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:1429 → 1481
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2163 → 2209
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:582 → 634
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    2. NM_001270013.3 → NP_001256942.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P658
      Conserved Domains (6) summary
      COG5665
      Location:1802 → 2040
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd00191
      Location:232 → 280
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:2047 → 2099
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2781 → 2827
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cd00109
      Location:608 → 658
      Kunitz-type; Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
      cd22626
      Location:2112 → 2162
      Kunitz_ixolaris_2; Kunitz-type domain 2 (K2) of Ixolaris, and similar proteins

    3. NM_001270011.3 → NP_001256940.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45881
      Conserved Domains (5) summary
      cd00109
      Location:735 → 787
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00191
      Location:361 → 409
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:1222 → 1274
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:1956 → 2002
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:803 → 855
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    4. NM_001270012.3 → NP_001256941.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P659
      Conserved Domains (6) summary
      COG5665
      Location:1922 → 2160
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd00191
      Location:361 → 409
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:2167 → 2219
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2901 → 2947
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cd00109
      Location:728 → 778
      Kunitz-type; Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
      cd22626
      Location:2232 → 2282
      Kunitz_ixolaris_2; Kunitz-type domain 2 (K2) of Ixolaris, and similar proteins

    5. NM_001270009.3 → NP_001256938.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9WRT9
      Conserved Domains (5) summary
      cd00109
      Location:735 → 787
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00191
      Location:361 → 409
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:2176 → 2228
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2910 → 2956
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:803 → 855
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    6. NM_001270010.3 → NP_001256939.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P660
      Conserved Domains (6) summary
      COG5665
      Location:1405 → 1643
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd00191
      Location:361 → 409
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:1650 → 1702
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2384 → 2430
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cd00109
      Location:737 → 787
      Kunitz-type; Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
      cd22626
      Location:1715 → 1765
      Kunitz_ixolaris_2; Kunitz-type domain 2 (K2) of Ixolaris, and similar proteins

    7. NM_001270014.3 → NP_001256943.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G336
      Conserved Domains (5) summary
      cd00109
      Location:514 → 566
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00191
      Location:140 → 188
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:1574 → 1626
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2308 → 2354
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:582 → 634
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    8. NM_001270016.3 → NP_001256945.1  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G334
      Conserved Domains (5) summary
      cd00109
      Location:505 → 557
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cd00191
      Location:140 → 188
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:1420 → 1472
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam14625
      Location:2154 → 2200
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00101
      Location:573 → 625
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    Nucleotide Protein
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