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    FAAH2 fatty acid amide hydrolase 2 [ Homo sapiens (human) ]

    Gene ID: 158584, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FAAH2provided by HGNC
    Official Full Name
    fatty acid amide hydrolase 2provided by HGNC
    Primary source
    HGNC:HGNC:26440
    See related
    Ensembl:ENSG00000165591 MIM:300654; AllianceGenome:HGNC:26440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMDD
    Summary
    This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in liver (RPKM 2.5), skin (RPKM 1.5) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FAAH2 in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (57121591..57489196)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (56420423..56788009)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57313110..57515629)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPIN2 family pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:57143727-57144926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20870 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:57168413-57168642 Neighboring gene spindlin family member 2B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57203412-57203990 Neighboring gene spindlin family member 2A Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:57361506-57362334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:57362335-57363162 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57364391-57365161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:57392555-57393056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:57393057-57393556 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:57634195-57634694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:57673257-57673977 Neighboring gene NANOG hESC enhancer GRCh37_chrX:57677545-57678046 Neighboring gene uncharacterized LOC107985708 Neighboring gene zinc finger X-linked duplicated B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms. Sirrs S, et al. Orphanet J Rare Dis, 2015 Mar 28. PMID 25885783, Free PMC Article
    2. Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. Kaczocha M, et al. J Biol Chem, 2010 Jan 22. PMID 19926788, Free PMC Article
    3. A second fatty acid amide hydrolase with variable distribution among placental mammals. Wei BQ, et al. J Biol Chem, 2006 Dec 1. PMID 17015445
    4. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Karbarz MJ, et al. Anesth Analg, 2009 Jan. PMID 19095868
    5. Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression. Tang J, et al. Cells, 2022 Oct 28. PMID 36359803, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A male patient with neuropsychiatric disorders attributed to a FAAH2 missense mutation is described.
      Title: Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.
    2. results establish FAAH-2 as a bone fide N-acylethanolamine-catabolizing enzyme and suggest that inactivation is spatially separated in cells of higher mammals
      Title: Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.
    3. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
      Title: Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
    4. FAAH2 is the second membrane-associated AS enzyme in humans that displays FAAH activity
      Title: A second fatty acid amide hydrolase with variable distribution among placental mammals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of fatty acid amide hydrolase 2 (FAAH2) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid amide hydrolase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty-acid amide hydrolase 2
    Names
    amidase domain containing
    amidase domain-containing protein
    anandamide amidohydrolase 2
    oleamide hydrolase 2
    NP_001340769.1
    NP_001340770.1
    NP_777572.2
    XP_005262042.1
    XP_005262043.1
    XP_005262044.1
    XP_011529069.1
    XP_016884779.1
    XP_016884781.1
    XP_016884782.1
    XP_016884783.1
    XP_047297816.1
    XP_047297817.1
    XP_047297818.1
    XP_047297819.1
    XP_047297820.1
    XP_054182504.1
    XP_054182505.1
    XP_054182506.1
    XP_054182507.1
    XP_054182508.1
    XP_054182509.1
    XP_054182510.1
    XP_054182511.1
    XP_054182512.1
    XP_054182513.1
    XP_054182514.1
    XP_054182515.1
    XP_054182516.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013232.3 RefSeqGene

      Range
      170117..372604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001353840.1 → NP_001340769.1  fatty-acid amide hydrolase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL590394, AL606754, AL928898, BC073922, Z83745
      Conserved Domains (1) summary
      COG0154
      Location:48 → 486
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    2. NM_001353841.1 → NP_001340770.1  fatty-acid amide hydrolase 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL590394, AL606754, AL928898, BC073922, Z83745
      Conserved Domains (1) summary
      COG0154
      Location:48 → 456
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    3. NM_174912.4 → NP_777572.2  fatty-acid amide hydrolase 2 isoform 1

      See identical proteins and their annotated locations for NP_777572.2

      Status: REVIEWED

      Source sequence(s)
      AL590394, AL606754, AL928898, Z83745
      Consensus CDS
      CCDS14375.1
      UniProtKB/Swiss-Prot
      Q6GMR7, Q86VT2, Q96N98
      UniProtKB/TrEMBL
      B2C6G4
      Related
      ENSP00000364035.4, ENST00000374900.5
      Conserved Domains (1) summary
      COG0154
      Location:48 → 526
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_148557.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL590394, AL606754, AL928898, BC073922, Z83745

    2. NR_148564.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL590394, AL606754, AL928898, Z83745

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      57121591..57489196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530767.4 → XP_011529069.1  fatty-acid amide hydrolase 2 isoform X2

      See identical proteins and their annotated locations for XP_011529069.1

      Conserved Domains (1) summary
      COG0154
      Location:2 → 443
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    2. XM_005261985.4 → XP_005262042.1  fatty-acid amide hydrolase 2 isoform X2

      See identical proteins and their annotated locations for XP_005262042.1

      Conserved Domains (1) summary
      COG0154
      Location:2 → 443
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    3. XM_005261987.5 → XP_005262044.1  fatty-acid amide hydrolase 2 isoform X10

      Conserved Domains (1) summary
      COG0154
      Location:48 → 321
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    4. XM_047441861.1 → XP_047297817.1  fatty-acid amide hydrolase 2 isoform X4

    5. XM_047441864.1 → XP_047297820.1  fatty-acid amide hydrolase 2 isoform X12

    6. XM_017029290.3 → XP_016884779.1  fatty-acid amide hydrolase 2 isoform X1

    7. XM_047441860.1 → XP_047297816.1  fatty-acid amide hydrolase 2 isoform X3

    8. XM_017029292.2 → XP_016884781.1  fatty-acid amide hydrolase 2 isoform X5

    9. XM_047441862.1 → XP_047297818.1  fatty-acid amide hydrolase 2 isoform X6

    10. XM_017029294.3 → XP_016884783.1  fatty-acid amide hydrolase 2 isoform X8

    11. XM_017029293.3 → XP_016884782.1  fatty-acid amide hydrolase 2 isoform X7

    12. XM_005261986.5 → XP_005262043.1  fatty-acid amide hydrolase 2 isoform X9

      Conserved Domains (1) summary
      COG0154
      Location:48 → 321
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]

    13. XM_047441863.1 → XP_047297819.1  fatty-acid amide hydrolase 2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      56420423..56788009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326530.1 → XP_054182505.1  fatty-acid amide hydrolase 2 isoform X2

    2. XM_054326531.1 → XP_054182506.1  fatty-acid amide hydrolase 2 isoform X2

    3. XM_054326539.1 → XP_054182514.1  fatty-acid amide hydrolase 2 isoform X10

    4. XM_054326533.1 → XP_054182508.1  fatty-acid amide hydrolase 2 isoform X4

    5. XM_054326541.1 → XP_054182516.1  fatty-acid amide hydrolase 2 isoform X12

    6. XM_054326529.1 → XP_054182504.1  fatty-acid amide hydrolase 2 isoform X1

    7. XM_054326532.1 → XP_054182507.1  fatty-acid amide hydrolase 2 isoform X3

    8. XM_054326534.1 → XP_054182509.1  fatty-acid amide hydrolase 2 isoform X5

    9. XM_054326535.1 → XP_054182510.1  fatty-acid amide hydrolase 2 isoform X6

    10. XM_054326537.1 → XP_054182512.1  fatty-acid amide hydrolase 2 isoform X8

    11. XM_054326536.1 → XP_054182511.1  fatty-acid amide hydrolase 2 isoform X7

    12. XM_054326538.1 → XP_054182513.1  fatty-acid amide hydrolase 2 isoform X9

    13. XM_054326540.1 → XP_054182515.1  fatty-acid amide hydrolase 2 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GMR7.1 GenPept UniProtKB/Swiss-Prot:Q6GMR7

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