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    ENOX2 ecto-NOX disulfide-thiol exchanger 2 [ Homo sapiens (human) ]

    Gene ID: 10495, updated on 10-Dec-2024

    Summary

    Official Symbol
    ENOX2provided by HGNC
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 2provided by HGNC
    Primary source
    HGNC:HGNC:2259
    See related
    Ensembl:ENSG00000165675 MIM:300282; AllianceGenome:HGNC:2259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APK1; tNOX; COVA1
    Summary
    This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in adrenal (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ENOX2 in Genome Data Viewer
    Location:
    Xq26.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (130622325..130903209, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (128942086..129222979, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129756299..130037183, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:129651017-129651626 Neighboring gene DENND10 pseudogene 1 Neighboring gene uncharacterized LOC105373336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129706680-129707280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129707281-129707881 Neighboring gene GATA motif-containing MPRA enhancer 234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29943 Neighboring gene SPRING1 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chrX:129847027-129847528 Neighboring gene Sharpr-MPRA regulatory region 3134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129853011-129853512 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:129872422-129873176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29944 Neighboring gene ENOX2 antisense RNA 1 Neighboring gene uncharacterized LOC124905217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29945 Neighboring gene H3K27ac hESC enhancers GRCh37_chrX:130036549-130037068 and GRCh37_chrX:130037069-130037588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:130093191-130093716 Neighboring gene long intergenic non-protein coding RNA 1201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130191672-130192325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130192326-130192978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130206444-130207164 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:130218349-130219548 Neighboring gene Rho GTPase activating protein 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in electron transport chain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ultradian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ecto-NOX disulfide-thiol exchanger 2
    Names
    APK1 antigen
    cytosolic ovarian carcinoma antigen 1
    ecto-NADPH oxidase disulfide-thiol exchanger 2
    tumor-associated NADH oxidase
    tumor-associated hydroquinone oxidase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012562.2 RefSeqGene

      Range
      5026..285910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281736.2NP_001268665.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_001268665.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (a) which is shorter at the N-terminus, compared to isoform b.
      Source sequence(s)
      AI540639, AK000353, AL591908, BC108713, BC140874
      Consensus CDS
      CCDS14627.1
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Related
      ENSP00000359973.1, ENST00000370935.5
      Conserved Domains (2) summary
      COG0724
      Location:90168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    2. NM_001382516.1NP_001369445.1  ecto-NOX disulfide-thiol exchanger 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049565, AL049733, AL591908, Z80232
      Consensus CDS
      CCDS14626.1
      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Conserved Domains (2) summary
      COG1196
      Location:293526
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    3. NM_001382517.1NP_001369446.1  ecto-NOX disulfide-thiol exchanger 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049733, AL591908
      Consensus CDS
      CCDS14626.1
      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Conserved Domains (2) summary
      COG1196
      Location:293526
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    4. NM_001382518.1NP_001369447.1  ecto-NOX disulfide-thiol exchanger 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049733, AL591908, Z80232
      Consensus CDS
      CCDS94664.1
      UniProtKB/TrEMBL
      A0A8I5KRI1, A4QPE1
      Related
      ENSP00000509235.1, ENST00000686943.1
      Conserved Domains (2) summary
      COG1196
      Location:356589
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:185268
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    5. NM_001382519.1NP_001369448.1  ecto-NOX disulfide-thiol exchanger 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049733, AL591908, Z80232
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Conserved Domains (2) summary
      PTZ00121
      Location:342507
      PTZ00121; MAEBL; Provisional
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    6. NM_001382520.1NP_001369449.1  ecto-NOX disulfide-thiol exchanger 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049733, AL591908
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Conserved Domains (2) summary
      PTZ00121
      Location:342507
      PTZ00121; MAEBL; Provisional
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    7. NM_001382521.1NP_001369450.1  ecto-NOX disulfide-thiol exchanger 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049733, AL591908
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Conserved Domains (2) summary
      PTZ00121
      Location:313478
      PTZ00121; MAEBL; Provisional
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    8. NM_001382522.1NP_001369451.1  ecto-NOX disulfide-thiol exchanger 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL022153, AL049733, AL591908, Z80232
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Conserved Domains (2) summary
      PTZ00121
      Location:313478
      PTZ00121; MAEBL; Provisional
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    9. NM_006375.4NP_006366.2  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_006366.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (a) which is shorter at the N-terminus, compared to isoform b.
      Source sequence(s)
      AI540639, AK289837, AL591908, BC140874
      Consensus CDS
      CCDS14627.1
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Related
      ENSP00000377890.1, ENST00000394363.6
      Conserved Domains (2) summary
      COG0724
      Location:90168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    10. NM_182314.3NP_872114.1  ecto-NOX disulfide-thiol exchanger 2 isoform b

      See identical proteins and their annotated locations for NP_872114.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b).
      Source sequence(s)
      AI540639, AK000353, AK289812, AL591908, BC140874
      Consensus CDS
      CCDS14626.1
      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Related
      ENSP00000337146.3, ENST00000338144.8
      Conserved Domains (2) summary
      COG1196
      Location:293526
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      130622325..130903209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441768.1XP_047297724.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BI25
    2. XM_047441767.1XP_047297723.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25
    3. XM_011531245.3XP_011529547.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

      UniProtKB/TrEMBL
      A4QPE1
      Conserved Domains (2) summary
      COG0724
      Location:182260
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:185268
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    4. XM_047441769.1XP_047297725.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    5. XM_047441766.1XP_047297722.1  ecto-NOX disulfide-thiol exchanger 2 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BI24, A4QPE1
      Related
      ENSP00000519773.1, ENST00000714528.1
    6. XM_047441770.1XP_047297726.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    7. XM_047441771.1XP_047297727.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    8. XM_047441772.1XP_047297728.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    9. XM_047441773.1XP_047297729.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    10. XM_011531249.3XP_011529551.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      See identical proteins and their annotated locations for XP_011529551.1

      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25
      Related
      ENSP00000359965.1, ENST00000370927.5
      Conserved Domains (2) summary
      COG1196
      Location:293526
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      128942086..129222979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326374.1XP_054182349.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BI25
    2. XM_054326372.1XP_054182347.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25
    3. XM_054326370.1XP_054182345.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

      UniProtKB/TrEMBL
      A4QPE1
    4. XM_054326375.1XP_054182350.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    5. XM_054326371.1XP_054182346.1  ecto-NOX disulfide-thiol exchanger 2 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BI24, A4QPE1
    6. XM_054326376.1XP_054182351.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    7. XM_054326377.1XP_054182352.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    8. XM_054326378.1XP_054182353.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0AAQ5BI25
    9. XM_054326373.1XP_054182348.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      A8K197, A8K1C2, Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82
      UniProtKB/TrEMBL
      A0AAQ5BI25