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    ADGRD2 adhesion G protein-coupled receptor D2 [ Homo sapiens (human) ]

    Gene ID: 347088, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADGRD2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor D2provided by HGNC
    Primary source
    HGNC:HGNC:18651
    See related
    Ensembl:ENSG00000180264 MIM:620837; AllianceGenome:HGNC:18651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR24; GPR144
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRD2 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124450451..124478580)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (136648682..136676809)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127212730..127240859)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106555 Neighboring gene uncharacterized LOC124902267 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127162229-127162772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127162773-127163315 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:127173920-127175119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28985 Neighboring gene uncharacterized LOC105376270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127202115-127202615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127212355-127212879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127212880-127213404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127213405-127213929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127244219-127244996 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127248727-127248904 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127263337-127263838 Neighboring gene NR5A1 5' promoter region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127274335-127274887 Neighboring gene nuclear receptor subfamily 5 group A member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127297992-127298492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28986 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:127336756-127337955 Neighboring gene RAN binding protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Secretin GPCRs descended from the family of Adhesion GPCRs. Nordström KJ, et al. Mol Biol Evol, 2009 Jan. PMID 18845549
    2. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor D2; adhesion G-protein coupled receptor D2
    Names
    G protein-coupled receptor PGR24
    G-protein coupled receptor 144
    G-protein coupled receptor GPR144

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395425.1 → NP_001382354.1  adhesion G protein-coupled receptor D2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL137846
      Consensus CDS
      CCDS94480.1
      UniProtKB/TrEMBL
      A0A8Q3SIF2, A0A9L9PY34
      Related
      ENSP00000512565.1, ENST00000696331.1
      Conserved Domains (4) summary
      cd00037
      Location:50 → 73
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd15255
      Location:692 → 954
      7tmB2_GPR144; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02559
      Location:646 → 685
      GPS; GPCR proteolysis site, GPS, motif
      cl22861
      Location:111 → 297
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      124450451..124478580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423337.1 → XP_047279293.1  adhesion G-protein coupled receptor D2 isoform X1

    2. XM_047423338.1 → XP_047279294.1  adhesion G-protein coupled receptor D2 isoform X1

    3. XM_047423339.1 → XP_047279295.1  adhesion G-protein coupled receptor D2 isoform X2

      UniProtKB/TrEMBL
      A0A8Q3SIF2, A0A9L9PY34

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      136648682..136676809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362908.1 → XP_054218883.1  adhesion G-protein coupled receptor D2 isoform X2

      UniProtKB/TrEMBL
      A0A9L9PY34

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001161808.1: Suppressed sequence

      Description
      NM_001161808.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_182611.2: Suppressed sequence

      Description
      NM_182611.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7M1.1 GenPept UniProtKB/Swiss-Prot:Q7Z7M1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials