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    ZNF710 zinc finger protein 710 [ Homo sapiens (human) ]

    Gene ID: 374655, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF710provided by HGNC
    Official Full Name
    zinc finger protein 710provided by HGNC
    Primary source
    HGNC:HGNC:25352
    See related
    Ensembl:ENSG00000140548 AllianceGenome:HGNC:25352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.2), spleen (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF710 in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (89998307..90082191)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87754311..87838222)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90544556..90625423)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90452345-90452529 Neighboring gene RNA, U7 small nuclear 111 pseudogene Neighboring gene actin related protein 2/3 complex inhibitor Neighboring gene zinc finger and SCAN domain containing 5A pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90525469-90526190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6807 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90544586-90544754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90545369-90546137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90546138-90546905 Neighboring gene microRNA 3174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90581285-90581804 Neighboring gene Sharpr-MPRA regulatory region 12348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90585951-90586930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90597371-90598254 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90602135-90602846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90627210-90627710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90627711-90628211 Neighboring gene ZNF710 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90630317-90631230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90634376-90634876 Neighboring gene NANOG hESC enhancer GRCh37_chr15:90638658-90639182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90644126-90644981 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90644982-90645836 Neighboring gene isocitrate dehydrogenase (NADP(+)) 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90664819-90665318 Neighboring gene IDH2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 4454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90686773-90687307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90701094-90701611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90701612-90702128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90704142-90704734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90704735-90705327 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90707039-90707194 Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of antisense long non‑coding RNA ZNF710‑AS1‑202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression. Li G, et al. Mol Med Rep, 2020 Jun. PMID 32236626, Free PMC Article
    2. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of antisense long noncoding RNA ZNF710AS1202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression.
      Title: Overexpression of antisense long non‑coding RNA ZNF710‑AS1‑202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00306, FLJ37393, MGC163413, DKFZp547K1113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 710

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198526.4 → NP_940928.2  zinc finger protein 710

      See identical proteins and their annotated locations for NP_940928.2

      Status: VALIDATED

      Source sequence(s)
      AC087284, AK160373, AL831826, BC020301, BC126476
      Consensus CDS
      CCDS10358.1
      UniProtKB/Swiss-Prot
      A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0
      Related
      ENSP00000268154.3, ENST00000268154.9
      Conserved Domains (4) summary
      COG5048
      Location:335 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:297 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:435 → 457
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:534 → 558
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      89998307..90082191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432486.1 → XP_047288442.1  zinc finger protein 710 isoform X4

    2. XM_011521543.4 → XP_011519845.2  zinc finger protein 710 isoform X6

    3. XM_047432483.1 → XP_047288439.1  zinc finger protein 710 isoform X2

    4. XM_047432482.1 → XP_047288438.1  zinc finger protein 710 isoform X1

    5. XM_005254907.5 → XP_005254964.1  zinc finger protein 710 isoform X3

      See identical proteins and their annotated locations for XP_005254964.1

      Conserved Domains (4) summary
      COG5048
      Location:335 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:297 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:435 → 457
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:534 → 558
      zf-H2C2_2; Zinc-finger double domain

    6. XM_047432487.1 → XP_047288443.1  zinc finger protein 710 isoform X5

      UniProtKB/Swiss-Prot
      A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

    7. XM_047432488.1 → XP_047288444.1  zinc finger protein 710 isoform X5

      UniProtKB/Swiss-Prot
      A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

    8. XM_005254906.5 → XP_005254963.1  zinc finger protein 710 isoform X3

      See identical proteins and their annotated locations for XP_005254963.1

      Conserved Domains (4) summary
      COG5048
      Location:335 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:297 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:435 → 457
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:534 → 558
      zf-H2C2_2; Zinc-finger double domain

    9. XM_011521542.4 → XP_011519844.1  zinc finger protein 710 isoform X3

      See identical proteins and their annotated locations for XP_011519844.1

      Conserved Domains (4) summary
      COG5048
      Location:335 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:297 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:435 → 457
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:534 → 558
      zf-H2C2_2; Zinc-finger double domain

    10. XM_047432484.1 → XP_047288440.1  zinc finger protein 710 isoform X3

    11. XM_047432485.1 → XP_047288441.1  zinc finger protein 710 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      87754311..87838222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377888.1 → XP_054233863.1  zinc finger protein 710 isoform X4

    2. XM_054377881.1 → XP_054233856.1  zinc finger protein 710 isoform X1

    3. XM_054377891.1 → XP_054233866.1  zinc finger protein 710 isoform X6

    4. XM_054377882.1 → XP_054233857.1  zinc finger protein 710 isoform X2

    5. XM_054377883.1 → XP_054233858.1  zinc finger protein 710 isoform X3

    6. XM_054377884.1 → XP_054233859.1  zinc finger protein 710 isoform X3

    7. XM_054377886.1 → XP_054233861.1  zinc finger protein 710 isoform X3

    8. XM_054377889.1 → XP_054233864.1  zinc finger protein 710 isoform X5

      UniProtKB/Swiss-Prot
      A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

    9. XM_054377890.1 → XP_054233865.1  zinc finger protein 710 isoform X5

      UniProtKB/Swiss-Prot
      A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

    10. XM_054377887.1 → XP_054233862.1  zinc finger protein 710 isoform X3

    11. XM_054377885.1 → XP_054233860.1  zinc finger protein 710 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N1W2.2 GenPept UniProtKB/Swiss-Prot:Q8N1W2

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