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    H4C15 H4 clustered histone 15 [ Homo sapiens (human) ]

    Gene ID: 554313, updated on 27-Dec-2024

    Summary

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    Official Symbol
    H4C15provided by HGNC
    Official Full Name
    H4 clustered histone 15provided by HGNC
    Primary source
    HGNC:HGNC:29607
    See related
    Ensembl:ENSG00000270276 AllianceGenome:HGNC:29607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H4/o; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4-16; H4C11; H4C12; H4C13; H4C14; H4C16; HIST2H4B
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H4 family. Some transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, May 2020]
    Orthologs
    all
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    Genomic context

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    See H4C15 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149844488..149861240, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148978230..148985386, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149825657..149832725, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:149816892-149817655 Neighboring gene H2A clustered histone 18 Neighboring gene H2B clustered histone 19, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149822691-149823368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149824048-149824725 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149824726-149825404 Neighboring gene H2B clustered histone 20, pseudogene Neighboring gene H2A clustered histone 19 Neighboring gene H3 clustered histone 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149856835-149857428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1660 Neighboring gene H2B clustered histone 21 Neighboring gene H2A clustered histone 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. Hovhannisyan H, et al. Mol Cell Biol, 2003 Feb. PMID 12556504, Free PMC Article
    2. Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells. Holmes WF, et al. J Biol Chem, 2005 Nov 11. PMID 16131487
    3. A major human histone gene cluster on the long arm of chromosome 1. Green L, et al. Science, 1984 Nov 16. PMID 6494913
    4. Identification and characterization of two closely related histone H4 arginine 3 methyltransferases in Arabidopsis thaliana. Yan D, et al. Biochem J, 2007 Nov 15. PMID 17666011, Free PMC Article
    5. Proapoptotic function of the retinoblastoma tumor suppressor protein. Ianari A, et al. Cancer Cell, 2009 Mar 3. PMID 19249677, Free PMC Article

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to CENP-A containing chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in telomere organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CENP-A containing nucleosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nucleosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H4
    Names
    histone 2, H4b
    histone cluster 2 H4 family member b
    histone cluster 2, H4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034077.4 → NP_001029249.1  histone H4

      See identical proteins and their annotated locations for NP_001029249.1

      Status: REVIEWED

      Source sequence(s)
      AC239868
      Consensus CDS
      CCDS30851.1
      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0
      Related
      ENSP00000462355.1, ENST00000579512.3
      Conserved Domains (1) summary
      PLN00035
      Location:1 → 103
      PLN00035; histone H4; Provisional

    RNA

    1. NR_168446.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC239868

    2. NR_168447.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC239868

    3. NR_168448.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC239868

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      149844488..149861240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424442.1 → XP_047280398.1  histone H4 isoform X1

      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0

    2. XM_047424439.1 → XP_047280395.1  histone H4 isoform X1

      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0

    3. XM_024451708.2 → XP_024307476.2  histone H4 isoform X1

      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0

    4. XM_047424434.1 → XP_047280390.1  histone H4 isoform X1

      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0

    5. XM_047424436.1 → XP_047280392.1  histone H4 isoform X1

      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0
      Related
      ENSP00000482412.1, ENST00000612061.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      148978230..148985386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337526.1 → XP_054193501.1  histone H4 isoform X1

      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62805.2 GenPept UniProtKB/Swiss-Prot:P62805

    Gene LinkOut

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