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    tal-1A tarsal-less 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354381, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tal-1Aprovided by FlyBase
    Official Full Name
    tarsal-less 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259730
    Locus tag
    Dmel_CG42384
    See related
    AllianceGenome:FB:FBgn0259730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42384; Dm1; Dmel\CG42384; ORF 1A; ORF1; Pep1; pri; Pri; tal; Tal1A
    Summary
    Involved in actin filament organization and morphogenesis of an epithelium. Is expressed in several structures, including antennal anlage; central brain anlage; dorsal head epidermis anlage; embryonic anal pad; and gut section. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See tal-1A in Genome Data Viewer
    Location:
    87F14-87F14; 3-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13813109..13814648)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9638831..9640370)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Phenylalanine-GAA 1-6 Neighboring gene transfer RNA:Phenylalanine-GAA 1-7 Neighboring gene tarsal-less 2A Neighboring gene tarsal-less AA Neighboring gene tarsal-less 3A Neighboring gene long non-coding RNA:CR43641 Neighboring gene long non-coding RNA:CR43642

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pri sORF peptides induce selective proteasome-mediated protein processing. Zanet J, et al. Science, 2015 Sep 18. PMID 26383956
    2. A segmentation gene in tribolium produces a polycistronic mRNA that codes for multiple conserved peptides. Savard J, et al. Cell, 2006 Aug 11. PMID 16901788
    3. Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis. Kondo T, et al. Science, 2010 Jul 16. PMID 20647469
    4. Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses. Dib A, et al. Front Genet, 2021. PMID 34527021, Free PMC Article
    5. The 11-aminoacid long Tarsal-less peptides trigger a cell signal in Drosophila leg development. Pueyo JI, et al. Dev Biol, 2008 Dec 15. PMID 18801356

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor.
      Title: Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor.
    2. Tarsal-less triggers a cell signal which implements the patterning activity of a tarsal boundary during leg development.
      Title: The 11-aminoacid long Tarsal-less peptides trigger a cell signal in Drosophila leg development.
    3. tal controls gene expression and tissue folding in Drosophila, thus acting as a link between patterning and morphogenesis. tal function is mediated by several 33-nucleotide-long open reading frames, which are translated into 11-amino-acid-long peptides.
      Title: Peptides encoded by short ORFs control development and define a new eukaryotic gene family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tarsal-less 1A
    Names
    CG42384-PB
    tal-1A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13813109..13814648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144578.2 → NP_001138050.1  tarsal-less 1A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3RLQ8, C0HJX4, C0HJX5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HJX4.1 C0HJX4
    C0HJX5.1

    Gene LinkOut

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    Research Materials