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    Dbx Dbx [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38254, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dbxprovided by FlyBase
    Official Full Name
    Dbxprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261723
    Locus tag
    Dmel_CG42234
    See related
    AllianceGenome:FB:FBgn0261723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12361; CG13925; CG42234; dbx; DBX; dDbx; Dmel\CG42234
    Old locus tag
    Dmel_CG12361; Dmel_CG13925
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in axon guidance and neuron fate commitment. Is expressed in NB3-2 lineage neurons and segmentally-repeated neuroblast. Orthologous to human DBX1 (developing brain homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dbx in Genome Data Viewer
    Location:
    62B10-62B11; 3-1.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1921307..1933602)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1921307..1933602)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tetraspan membrane protein in hair cell stereocilia Neighboring gene debris buster Neighboring gene transfer RNA:Cysteine-GCA 2-1 Neighboring gene long non-coding RNA:CR45826 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44536 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9. Lacin H, et al. Development, 2009 Oct. PMID 19710170, Free PMC Article
    2. Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS. Lacin H, et al. Elife, 2020 Mar 27. PMID 32216875, Free PMC Article
    3. A branching gene regulatory network dictating different aspects of a neuronal cell identity. Stratmann J, et al. Development, 2019 Mar 15. PMID 30837222
    4. How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits. Meng JL, et al. Elife, 2019 Sep 10. PMID 31502540, Free PMC Article
    5. Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons. Touma JJ, et al. Development, 2012 Feb. PMID 22219354

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dbx
    Names
    CG42234-PC
    Dbx-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1921307..1933602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139420.4 → NP_647677.2  Dbx [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647677.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W064
      Conserved Domains (1) summary
      pfam00046
      Location:437 → 490
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W064 Q9W064

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