flz filzig [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: flzprovided by FlyBase
Official Full Name: filzigprovided by FlyBase
Primary source: FLYBASE:FBgn0286782
Locus tag: Dmel_CG8213
See related: AllianceGenome:FB:FBgn0286782
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c-SP44; CG8213; cSP44; Dmel\CG8213; lint; SP44
Summary: Predicted to enable serine-type endopeptidase activity. Involved in lumen formation, open tracheal system and trachea morphogenesis. Located in perivitelline space. Is expressed in several structures, including adult brain cell body rind; adult tracheal system; epithelium; foregut primordium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44F12-45A1; 2-59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8969346..8985900, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4856851..4873405, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lint, a transmembrane serine protease, regulates growth and metabolism in Drosophila.
Title: Lint, a transmembrane serine protease, regulates growth and metabolism in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in lumen formation, open tracheal system	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISM Inferred from Sequence Model more info	PubMed
involved_in trachea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in perivitelline space	HDA more info	PubMed

General protein information

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Preferred Names: filzig

Names: CG8213-PB; CG8213-PC; CG8213-PD; flz-PB; flz-PC; flz-PD; lumens interrupted

NP_001137622.1

EC 3.4.21.-

NP_001286221.1

EC 3.4.21.-

NP_610435.4

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8969346..8985900 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136591.5 → NP_610435.4 filzig, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610435.4

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY35

Conserved Domains (4) summary

smart00020
Location:1429 → 1666

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:1430 → 1670

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam03353
Location:661 → 786

Lin-8; Ras-mediated vulval-induction antagonizt

pfam07382
Location:1288 → 1378

HC2; Histone H1-like nucleoprotein HC2
NM_001299292.1 → NP_001286221.1 filzig, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286221.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFV3

Conserved Domains (2) summary

pfam03353
Location:661 → 786

Lin-8; Ras-mediated vulval-induction antagonizt

pfam07382
Location:1288 → 1378

HC2; Histone H1-like nucleoprotein HC2
NM_001144150.2 → NP_001137622.1 filzig, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137622.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4LFV3, A1Z7M1, B7YZU2, Q8SY35

Conserved Domains (5) summary

PHA03247
Location:792 → 1096

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:547 → 1005

PRK10263; DNA translocase FtsK; Provisional

PRK11633
Location:365 → 439

PRK11633; cell division protein DedD; Provisional

PRK14948
Location:272 → 452

PRK14948; DNA polymerase III subunit gamma/tau

cd00190
Location:1449 → 1689

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...