Cfap119 cilia and flagella associated protein 119 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfap119provided by RGD
Official Full Name: cilia and flagella associated protein 119provided by RGD
Primary source: RGD:1593368
See related: EnsemblRapid:ENSRNOG00000053015 AllianceGenome:RGD:1593368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc189; Spergen-4
Summary: Predicted to act upstream of or within gene expression; single fertilization; and sperm flagellum assembly. Located in acrosomal vesicle and sperm principal piece. Orthologous to human CFAP119 (cilia and flagella associated protein 119). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 150.4), Lung (RPKM 40.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191627662..191647429, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182197171..182216936, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199032105..199037267, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that Spergen-4 integrated into elongated spermatids during spermiogenesis serves as a constituent for acrosome region and flagella of rat spermatozoa.
Title: Molecular Cloning of Spergen-4, Encoding a Spermatogenic Cell-Specific Protein Associated with Sperm Flagella and the Acrosome Region in Rat Spermatozoa.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm flagellum assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
NOT located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of radial spoke	ISO Inferred from Sequence Orthology more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cilia- and flagella-associated protein 119

Names: coiled-coil domain containing 189; coiled-coil domain-containing protein 189; coiled-coil domain-containing protein C16orf93 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134694.2 → NP_001128166.2 cilia- and flagella-associated protein 119

See identical proteins and their annotated locations for NP_001128166.2

Status: VALIDATED

Source sequence(s)

BC158625

UniProtKB/Swiss-Prot

A0A0H5BIB4, B0BMZ6, F1LNM9

UniProtKB/TrEMBL

A6I9R7

Conserved Domains (1) summary

pfam14769
Location:130 → 224

CLAMP; Flagellar C1a complex subunit C1a-32

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

191627662..191647429 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091721.1 → XP_038947649.1 cilia- and flagella-associated protein 119 isoform X5

Conserved Domains (1) summary

pfam14769
Location:50 → 146

CLAMP; Flagellar C1a complex subunit C1a-32
XM_039091696.2 → XP_038947624.1 cilia- and flagella-associated protein 119 isoform X1

Conserved Domains (1) summary

pfam14769
Location:207 → 261

CLAMP; Flagellar C1a complex subunit C1a-32
XM_039091718.2 → XP_038947646.1 cilia- and flagella-associated protein 119 isoform X4
XM_039091703.2 → XP_038947631.1 cilia- and flagella-associated protein 119 isoform X2

Conserved Domains (1) summary

pfam14769
Location:207 → 240

CLAMP; Flagellar C1a complex subunit C1a-32
XM_039091713.2 → XP_038947641.1 cilia- and flagella-associated protein 119 isoform X3

Conserved Domains (1) summary

pfam14769
Location:207 → 261

CLAMP; Flagellar C1a complex subunit C1a-32