Hao1 hydroxyacid oxidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hao1provided by RGD
Official Full Name: hydroxyacid oxidase 1provided by RGD
Primary source: RGD:1589750
See related: EnsemblRapid:ENSRNOG00000004601 AllianceGenome:RGD:1589750
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GOX; Gox1; XDH1; HAOX1
Summary: Predicted to enable (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and glyoxylate oxidase activity. Involved in response to oxidative stress. Located in peroxisome. Orthologous to human HAO1 (hydroxyacid oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1829.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (142102873..142281527, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (121757400..121828721, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (127444900..127500709, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The turnover of the enzyme and the rate constant for flavin were pH-independent, suggesting the involvement of an unprotonated group acting as a base in the chemical step of glycolate oxidation.
Title: Involvement of ionizable groups in catalysis of human liver glycolate oxidase.
Down-regulation of Hao1 during oxidative stress may provide mechanism to prevent excessive H2O2 formation in liver peroxisomes. May be prototype of response to oxidative injury involving down-regulation of reactive oxygen species-producing enzymes.
Title: Oxidative stress-mediated down-regulation of rat hydroxyacid oxidase 1, a liver-specific peroxisomal enzyme.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (S)-2-hydroxy-acid oxidase activity	ISO Inferred from Sequence Orthology more info
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables glyoxylate oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid alpha-oxidation	ISO Inferred from Sequence Orthology more info
involved_in glycine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycolate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-Hydroxyacid oxidase 1

Names: glycolate oxidase; glyoxylate oxidase; hydroxyacid oxidase (glycolate oxidase) 1; hydroxyacid oxidase 1, liver

NP_001101250.1

EC 1.1.3.15

EC 1.2.3.5

XP_038960945.1

EC 1.1.3.15

EC 1.2.3.5

XP_063139855.1

EC 1.1.3.15

EC 1.2.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107780.2 → NP_001101250.1 2-Hydroxyacid oxidase 1

See identical proteins and their annotated locations for NP_001101250.1

Status: PROVISIONAL

Source sequence(s)

BC158804

UniProtKB/Swiss-Prot

B0BNF9

Related

ENSRNOP00000006330.3, ENSRNOT00000006330.6

Conserved Domains (2) summary

cd02809
Location:9 → 357

alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

pfam01070
Location:16 → 362

FMN_dh; FMN-dependent dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

142102873..142281527 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283785.1 → XP_063139855.1 2-Hydroxyacid oxidase 1 isoform X1
XM_039105017.2 → XP_038960945.1 2-Hydroxyacid oxidase 1 isoform X2

Conserved Domains (1) summary

pfam01070
Location:1 → 310

FMN_dh; FMN-dependent dehydrogenase