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    APC APC, WNT signaling pathway regulator [ Gallus gallus (chicken) ]

    Gene ID: 415607, updated on 3-Dec-2024

    Summary

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    Symbol
    APCprovided by CGNC
    Full Name
    APC, WNT signaling pathway regulatorprovided by CGNC
    Primary source
    CGNC:50025
    See related
    Ensembl:ENSGALG00010008333
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    APC1; CTC-554D6.1
    Orthologs
    human mouse all
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    Genomic context

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    See APC in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (46692041..46785098, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (46692041..46785098, complement)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 5 Neighboring gene signal recognition particle 19 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC107052340 Neighboring gene small nucleolar RNA SNORA13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenomatous polyposis coli is differentially distributed in growth cones and modulates their steering. Koester MP, et al. J Neurosci, 2007 Nov 14. PMID 18003838, Free PMC Article
    2. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Nelson SA, et al. Dis Model Mech, 2012 Nov. PMID 22563063, Free PMC Article
    3. The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. Rosenberg MM, et al. J Neurosci, 2010 Aug 18. PMID 20720115, Free PMC Article
    4. Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Rosenberg MM, et al. Mol Cell Neurosci, 2008 Jun. PMID 18407517, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminal fragments of APC represent a gain-of-function mutation that causes cells within tissue to fail to migrate directionally.
      Title: Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems.
    2. Study defines a novel neural role for APC by showing that the postsynaptic APC multiprotein complex is required for anchoring neuroligin and neurexin at neuronal synapses in vivo.
      Title: The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo.
    3. new role for APC as an in vivo coordinator of nicotinic postsynaptic assembly in vertebrate neurons
      Title: Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex.
    4. Our data thus demonstrate a crucial role of APC for axon steering attributable to its multifunctional domain structure and differential distribution in the growth cone.
      Title: Adenomatous polyposis coli is differentially distributed in growth cones and modulates their steering.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables gamma-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pattern specification process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenomatous polyposis coli protein
    Names
    adenomatosis polyposis coli
    adenomatous polyposis coli 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      46692041..46785098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046905989.1 → XP_046761945.1  adenomatous polyposis coli protein isoform X10

      UniProtKB/TrEMBL
      A0A8V0XZP1
      Related
      ENSGALP00010011482.1, ENSGALT00010019934.1

    2. XM_040655703.2 → XP_040511637.1  adenomatous polyposis coli protein isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZP1
      Conserved Domains (5) summary
      pfam05483
      Location:5 → 262
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00185
      Location:690 → 730
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2289 → 2602
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:506 → 549
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

    3. XM_046905988.1 → XP_046761944.1  adenomatous polyposis coli protein isoform X7

      UniProtKB/TrEMBL
      A0A1D5PC88, A0A8V0Y267
      Related
      ENSGALP00010011489.1, ENSGALT00010019940.1

    4. XM_046905986.1 → XP_046761942.1  adenomatous polyposis coli protein isoform X5

      UniProtKB/TrEMBL
      A0A8V0Y267

    5. XM_046905985.1 → XP_046761941.1  adenomatous polyposis coli protein isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y267

    6. XM_046905987.1 → XP_046761943.1  adenomatous polyposis coli protein isoform X6

      UniProtKB/TrEMBL
      A0A8V0XZP1

    7. XM_046905990.1 → XP_046761946.1  adenomatous polyposis coli protein isoform X12

      UniProtKB/TrEMBL
      A0A8V0Y267

    8. XM_040655700.2 → XP_040511634.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y267
      Conserved Domains (4) summary
      smart00185
      Location:702 → 742
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2301 → 2614
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:518 → 561
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 67
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

    9. XM_040655705.2 → XP_040511639.1  adenomatous polyposis coli protein isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZP1
      Conserved Domains (5) summary
      pfam05483
      Location:5 → 262
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00185
      Location:690 → 730
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2289 → 2602
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:506 → 549
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

    10. XM_040655699.2 → XP_040511633.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y267
      Conserved Domains (4) summary
      smart00185
      Location:702 → 742
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2301 → 2614
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:518 → 561
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 67
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

    11. XM_040655710.2 → XP_040511644.1  adenomatous polyposis coli protein isoform X10

      UniProtKB/TrEMBL
      A0A8V0XZP1
      Related
      ENSGALP00010011495.1, ENSGALT00010019947.1
      Conserved Domains (16) summary
      smart00185
      Location:649 → 689
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:465 → 508
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam00514
      Location:691 → 731
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1642 → 1665
      APC_r; APC repeat
      pfam05924
      Location:2030 → 2049
      SAMP; SAMP Motif
      pfam05937
      Location:2668 → 2841
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2220 → 2565
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:732 → 1022
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1039 → 1138
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1287 → 1373
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1667 → 1720
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1751 → 1842
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1876 → 1943
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:393 → 466
      APC_rep; Adenomatous polyposis coli (APC) repeat

    12. XM_040655708.2 → XP_040511642.1  adenomatous polyposis coli protein isoform X8

      UniProtKB/TrEMBL
      A0A8V0XZP1, A0A8V0Y647
      Related
      ENSGALP00010011500.1, ENSGALT00010019952.1
      Conserved Domains (16) summary
      smart00185
      Location:657 → 697
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:473 → 516
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam00514
      Location:699 → 739
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1650 → 1673
      APC_r; APC repeat
      pfam05924
      Location:2038 → 2057
      SAMP; SAMP Motif
      pfam05937
      Location:2676 → 2849
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2228 → 2573
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:740 → 1030
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1047 → 1146
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1295 → 1381
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1675 → 1728
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1759 → 1850
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1884 → 1951
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:401 → 474
      APC_rep; Adenomatous polyposis coli (APC) repeat

    13. XM_040655704.2 → XP_040511638.1  adenomatous polyposis coli protein isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZP1
      Conserved Domains (5) summary
      pfam05483
      Location:5 → 262
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00185
      Location:690 → 730
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2289 → 2602
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:506 → 549
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

    14. XM_040655701.2 → XP_040511635.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y267
      Conserved Domains (4) summary
      smart00185
      Location:702 → 742
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2301 → 2614
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:518 → 561
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 67
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

    15. XM_040655711.2 → XP_040511645.1  adenomatous polyposis coli protein isoform X11

      UniProtKB/TrEMBL
      A0A8V0XXR0
      Conserved Domains (3) summary
      smart00185
      Location:576 → 616
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2175 → 2488
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:392 → 435
      ARM; armadillo repeat [structural motif]

    16. XM_040655709.2 → XP_040511643.1  adenomatous polyposis coli protein isoform X9

      UniProtKB/TrEMBL
      A0A8V0Y267
      Conserved Domains (3) summary
      smart00185
      Location:657 → 697
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2256 → 2569
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:473 → 516
      ARM; armadillo repeat [structural motif]

    17. XM_040655706.2 → XP_040511640.1  adenomatous polyposis coli protein isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y267
      Conserved Domains (3) summary
      smart00185
      Location:671 → 711
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:2270 → 2583
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:487 → 530
      ARM; armadillo repeat [structural motif]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      46692041..46785098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046935871.1 → XP_046791827.1  adenomatous polyposis coli protein isoform X10

      UniProtKB/TrEMBL
      A0A8V0XZP1

    2. XM_046935862.1 → XP_046791818.1  adenomatous polyposis coli protein isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZP1

    3. XM_046935868.1 → XP_046791824.1  adenomatous polyposis coli protein isoform X7

      UniProtKB/TrEMBL
      A0A1D5PC88, A0A8V0Y267

    4. XM_046935866.1 → XP_046791822.1  adenomatous polyposis coli protein isoform X5

      UniProtKB/TrEMBL
      A0A8V0Y267

    5. XM_046935861.1 → XP_046791817.1  adenomatous polyposis coli protein isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y267

    6. XM_046935867.1 → XP_046791823.1  adenomatous polyposis coli protein isoform X6

      UniProtKB/TrEMBL
      A0A8V0XZP1

    7. XM_046935874.1 → XP_046791830.1  adenomatous polyposis coli protein isoform X12

      UniProtKB/TrEMBL
      A0A8V0Y267

    8. XM_046935858.1 → XP_046791814.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y267

    9. XM_046935864.1 → XP_046791820.1  adenomatous polyposis coli protein isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZP1

    10. XM_046935860.1 → XP_046791816.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y267

    11. XM_046935872.1 → XP_046791828.1  adenomatous polyposis coli protein isoform X10

      UniProtKB/TrEMBL
      A0A8V0XZP1

    12. XM_046935869.1 → XP_046791825.1  adenomatous polyposis coli protein isoform X8

      UniProtKB/TrEMBL
      A0A8V0XZP1, A0A8V0Y647

    13. XM_046935863.1 → XP_046791819.1  adenomatous polyposis coli protein isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZP1

    14. XM_046935859.1 → XP_046791815.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y267

    15. XM_046935873.1 → XP_046791829.1  adenomatous polyposis coli protein isoform X11

      UniProtKB/TrEMBL
      A0A8V0XXR0

    16. XM_046935870.1 → XP_046791826.1  adenomatous polyposis coli protein isoform X9

      UniProtKB/TrEMBL
      A0A8V0Y267

    17. XM_046935865.1 → XP_046791821.1  adenomatous polyposis coli protein isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y267
    Nucleotide Protein Strain
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