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    LRX1 leucine-rich repeat/extensin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837756, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LRX1
    Official Full Name
    leucine-rich repeat/extensin 1
    Primary source
    TAIR:AT1G12040
    Locus tag
    AT1G12040
    See related
    Araport:AT1G12040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12F1.9; F12F1_9; leucine-rich repeat/extensin 1
    Summary
    encodes a a chimeric leucine-rich repeat/extensin protein that regulates root hair morphogenesis and elongation. Null mutants develop root hairs that frequently abort, swell, or branch. Gene is expressed in root hair cells and protein is specifically localized in the wall of the hair proper.
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    Genomic context

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    See LRX1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (4069992..4072681)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene phosphoenolpyruvate carboxylase, putative (DUF506) Neighboring gene ncRNA Neighboring gene fumarylacetoacetase Neighboring gene BCL-2-associated athanogene 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hydroxyproline-rich glycoprotein domain of the Arabidopsis LRX1 requires Tyr for function but not for insolubilization in the cell wall. Ringli C. Plant J, 2010 Aug. PMID 20545889
    2. The chimeric leucine-rich repeat/extensin cell wall protein LRX1 is required for root hair morphogenesis in Arabidopsis thaliana. Baumberger N, et al. Genes Dev, 2001 May 1. PMID 11331608, Free PMC Article
    3. The TOR pathway modulates the structure of cell walls in Arabidopsis. Leiber RM, et al. Plant Cell, 2010 Jun. PMID 20530756, Free PMC Article
    4. The Arabidopsis root hair cell wall formation mutant lrx1 is suppressed by mutations in the RHM1 gene encoding a UDP-L-rhamnose synthase. Diet A, et al. Plant Cell, 2006 Jul. PMID 16766693, Free PMC Article
    5. Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module. Gupta S, et al. PLoS Genet, 2024 Jan. PMID 38190412, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module.
      Title: Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module.
    2. Data show that modified LRX1 proteins lacking Tyr in the extensin domain are still insolubilized in the cell wall, indicating strong interactions of extensins within the cell wall in addition to the well-described Tyr cross-links.
      Title: The hydroxyproline-rich glycoprotein domain of the Arabidopsis LRX1 requires Tyr for function but not for insolubilization in the cell wall.
    3. ROL5 suppresses LRX1. Interfering with TOR signaling leads to suppression of lrx1.
      Title: The TOR pathway modulates the structure of cell walls in Arabidopsis.
    4. Data show that the Arabidopsis root hair cell wall formation mutant of LRX1 is suppressed by mutations in the RHM1 gene encoding a UDP-L-rhamnose synthase.
      Title: The Arabidopsis root hair cell wall formation mutant lrx1 is suppressed by mutations in the RHM1 gene encoding a UDP-L-rhamnose synthase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    NM_101076.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histidine phosphotransfer kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables structural constituent of cell wall ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat/extensin 1
    NP_172668.1
    • leucine-rich repeat/extensin 1 (LRX1); CONTAINS InterPro DOMAIN/s: Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611); BEST Arabidopsis thaliana protein match is: leucine-rich repeat/extensin 2 (TAIR:AT1G62440.1); Has 373279 Blast hits to 102116 proteins in 2982 species: Archae - 793; Bacteria - 62996; Metazoa - 122212; Fungi - 47201; Plants - 91548; Viruses - 7950; Other Eukaryotes - 40579 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4069992..4072681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101076.2 → NP_172668.1  leucine-rich repeat/extensin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65375
      UniProtKB/TrEMBL
      A0A5S9TXX0
      Conserved Domains (2) summary
      PLN00113
      Location:58 → 337
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:149 → 172
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65375.1

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