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    Mtnr1a melatonin receptor 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114211, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtnr1aprovided by RGD
    Official Full Name
    melatonin receptor 1Aprovided by RGD
    Primary source
    RGD:620797
    See related
    EnsemblRapid:ENSRNOG00000028744 AllianceGenome:RGD:620797
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Involved in camera-type eye development; circadian rhythm; and negative regulation of insulin secretion. Located in neuronal cell body. Biomarker of type 2 diabetes mellitus. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 4.2), Adrenal (RPKM 1.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Mtnr1a in Genome Data Viewer
    Location:
    16q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53876964..53896421, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (47144461..47163919, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50339358..50358809, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene coagulation factor XI Neighboring gene FAT atypical cadherin 1 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables melatonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables melatonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    melatonin receptor type 1A
    Names
    mel-1A-R
    mel1a melatonin receptor
    mel1a receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053676.2NP_446128.1  melatonin receptor type 1A

      See identical proteins and their annotated locations for NP_446128.1

      Status: PROVISIONAL

      Source sequence(s)
      AB377274
      UniProtKB/TrEMBL
      A6JPS4, B7X945, F7F7U1, Q9ESJ3
      Related
      ENSRNOP00000034328.3, ENSRNOT00000039331.5
      Conserved Domains (2) summary
      pfam00001
      Location:47298
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:38160
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      53876964..53896421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)