Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spsb3provided by MGI
Official Full Name: splA/ryanodine receptor domain and SOCS box containing 3provided by MGI
Primary source: MGI:MGI:1891471
See related: Ensembl:ENSMUSG00000024160 AllianceGenome:MGI:1891471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SSB3; Tce1; mKIAA4204; 2310012N15Rik; 3300001M01Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 50.0), thymus adult (RPKM 39.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.53 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25104956..25111124)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24885982..24892150)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of cGAS/STING signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SPRY domain-containing SOCS box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163750.2 → NP_001157222.2 SPRY domain-containing SOCS box protein 3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variants 2, 3, 5, and 6, encodes the longest isoform (a).

Source sequence(s)

AC166102

Consensus CDS

CCDS50022.1

UniProtKB/Swiss-Prot

Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0

Related

ENSMUSP00000112492.2, ENSMUST00000120943.8
NM_001163751.2 → NP_001157223.2 SPRY domain-containing SOCS box protein 3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).

Source sequence(s)

AC166102

UniProtKB/Swiss-Prot

Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0

Related

ENSMUSP00000112380.2, ENSMUST00000117890.8
NM_001374602.1 → NP_001361531.1 SPRY domain-containing SOCS box protein 3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).

Source sequence(s)

AC166102

UniProtKB/Swiss-Prot

Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0

UniProtKB/TrEMBL

A0A9S4GQ91

Conserved Domains (2) summary

cd12876
Location:104 → 286

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:276 → 312

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
NM_001400229.1 → NP_001387158.1 SPRY domain-containing SOCS box protein 3 isoform a

Status: VALIDATED

Source sequence(s)

AC166102

UniProtKB/Swiss-Prot

Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0
NM_001400231.1 → NP_001387160.1 SPRY domain-containing SOCS box protein 3 isoform b

Status: VALIDATED

Source sequence(s)

AC166102
NM_001400234.1 → NP_001387163.1 SPRY domain-containing SOCS box protein 3 isoform b

Status: VALIDATED

Source sequence(s)

AC166102

Related

ENSMUSP00000068567.7, ENSMUST00000068508.13
NM_001400235.1 → NP_001387164.1 SPRY domain-containing SOCS box protein 3 isoform c

Status: VALIDATED

Source sequence(s)

AC166102
NM_001400236.1 → NP_001387165.1 SPRY domain-containing SOCS box protein 3 isoform c

Status: VALIDATED

Source sequence(s)

AC166102
NM_001400237.1 → NP_001387166.1 SPRY domain-containing SOCS box protein 3 isoform c

Status: VALIDATED

Source sequence(s)

AC166102
NM_001400238.1 → NP_001387167.1 SPRY domain-containing SOCS box protein 3 isoform d

Status: VALIDATED

Source sequence(s)

AC166102
NM_027141.3 → NP_081417.3 SPRY domain-containing SOCS box protein 3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (a).

Source sequence(s)

AC166102

Consensus CDS

CCDS28501.1

UniProtKB/Swiss-Prot

Q3U0T8, Q571F5, Q6GQX9, Q8C6A9, Q8R4S9, Q9D7E0

Related

ENSMUSP00000024976.6, ENSMUST00000024976.5

RNA

NR_182655.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC166102

Related

ENSMUST00000134932.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25104956..25111124

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525170.5 → XP_006525233.1 SPRY domain-containing SOCS box protein 3 isoform X6

See identical proteins and their annotated locations for XP_006525233.1

UniProtKB/TrEMBL

A0A9S4GQ91, D3YW96

Related

ENSMUSP00000112589.2, ENSMUST00000119829.8

Conserved Domains (2) summary

cd12876
Location:104 → 311

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:301 → 337

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006525169.4 → XP_006525232.1 SPRY domain-containing SOCS box protein 3 isoform X5

UniProtKB/TrEMBL

A0A9S4GQ91

Conserved Domains (2) summary

cd12876
Location:135 → 342

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:332 → 368

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006525165.4 → XP_006525228.1 SPRY domain-containing SOCS box protein 3 isoform X1

Conserved Domains (2) summary

cd12876
Location:250 → 457

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:447 → 483

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006525166.5 → XP_006525229.1 SPRY domain-containing SOCS box protein 3 isoform X2

Conserved Domains (1) summary

cd12876
Location:250 → 414

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
XM_011246733.3 → XP_011245035.1 SPRY domain-containing SOCS box protein 3 isoform X6

See identical proteins and their annotated locations for XP_011245035.1

UniProtKB/TrEMBL

A0A9S4GQ91, D3YW96

Conserved Domains (2) summary

cd12876
Location:104 → 311

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:301 → 337

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006525168.5 → XP_006525231.1 SPRY domain-containing SOCS box protein 3 isoform X4

UniProtKB/TrEMBL

A0A9S4GQ91

Conserved Domains (2) summary

cd12876
Location:139 → 346

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:336 → 372

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_030250153.1 → XP_030106013.1 SPRY domain-containing SOCS box protein 3 isoform X9

Conserved Domains (2) summary

cd12876
Location:1 → 183

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:173 → 209

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...