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    SPESP1 sperm equatorial segment protein 1 [ Homo sapiens (human) ]

    Gene ID: 246777, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPESP1provided by HGNC
    Official Full Name
    sperm equatorial segment protein 1provided by HGNC
    Primary source
    HGNC:HGNC:15570
    See related
    Ensembl:ENSG00000258484 MIM:609399; AllianceGenome:HGNC:15570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESP; SP-ESP
    Summary
    The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. [provided by RefSeq, Apr 2010]
    Expression
    Biased expression in testis (RPKM 44.1), placenta (RPKM 5.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SPESP1 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68930525..68946811)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66753043..66769335)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69222864..69239150)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69103956-69104456 Neighboring gene ANP32A intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9651 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69109604-69110186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6591 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69111351-69111932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69111933-69112514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6594 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6595 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:69115796-69116596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9653 Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69167471-69168078 Neighboring gene MPRA-validated peak2374 silencer Neighboring gene SPESP1-NOX5 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69308141-69308642 Neighboring gene ATP binding cassette subfamily G member 2 (JR blood group) pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69318396-69318896 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:69328421-69329620 Neighboring gene NADPH oxidase 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69341256-69341437 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:69352321-69352820 Neighboring gene uncharacterized LOC124903515

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough SPESP1-NOX5

    Readthrough gene: SPESP1-NOX5, Included gene: NOX5

    Clone Names

    • MGC24663

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sperm-egg recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    sperm equatorial segment protein 1
    Names
    equatorial segment protein
    glycosylated 38 kDa sperm protein C-7/8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145658.4NP_663633.1  sperm equatorial segment protein 1 precursor

      See identical proteins and their annotated locations for NP_663633.1

      Status: REVIEWED

      Source sequence(s)
      AY358983, BC017998, BG720873
      Consensus CDS
      CCDS10230.1
      UniProtKB/Swiss-Prot
      Q6UW49, Q8NG22, Q8WVH8
      Related
      ENSP00000312284.3, ENST00000310673.4
      Conserved Domains (1) summary
      pfam15754
      Location:21338
      SPESP1; Sperm equatorial segment protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      68930525..68946811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      66753043..66769335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)