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    Gal beta galactosidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galprovided by FlyBase
    Official Full Name
    beta galactosidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001089
    Locus tag
    Dmel_CG9092
    See related
    AllianceGenome:FB:FBgn0001089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beta-gal; beta-GAL; beta-Gal-1; CG9092; dbeta-Gal; DmelGal; Dmel\CG9092; gal; lacZ-1
    Summary
    Enables beta-galactosidase activity and protein homodimerization activity. Involved in galactose metabolic process. Predicted to be active in vacuole. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to several human genes including GLB1L (galactosidase beta 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gal in Genome Data Viewer
    Location:
    26B2-26B2; 2-18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6003574..6006827, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6003574..6006827, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene infertile crescent Neighboring gene Lysine demethylase 5 Neighboring gene Tetraspanin 26A Neighboring gene antisense RNA:CR43866 Neighboring gene uncharacterized protein Neighboring gene Homeodomain protein 2.0

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The two origins of hemocytes in Drosophila. Holz A, et al. Development, 2003 Oct. PMID 12930778
    2. The effect of juvenile hormone on the response of the Drosophila imaginal disc cell line Cl 8+ to moulting hormone. Cottam DM, et al. J Insect Physiol, 1998 Dec. PMID 12770312
    3. Protocol to measure ß-galactosidase in Drosophila extracts using a CPRG assay. Barwell T, et al. STAR Protoc, 2022 Dec 16. PMID 36595888, Free PMC Article
    4. Synthesis of a new substrate for detection of lacZ gene expression in live Drosophila embryos. Minden JS. Biotechniques, 1996 Jan. PMID 8770416
    5. Endogenous beta-galactosidase activity in the larval, pupal, and adult stages of the fruit fly, Drosophila melanogaster, indicates need for caution in lacZ fusion-gene studies. Schnetzer JW, et al. Biol Bull, 1996 Apr. PMID 8652729

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional loss of glucocerebrosidase or beta-Gal promotes toxic conversion of alphaSyn via aberrant interactions between alphaSyn and their substrate glycolipids, leading to aggravation of alphaSyn-mediated neurodegeneration.
      Title: Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables beta-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in glycoprotein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta galactosidase
    Names
    CG9092-PA
    CG9092-PB
    Gal-PA
    Gal-PB
    beta-galactosidase
    beta-galactosidase-1
    NP_001260120.1
    NP_608978.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6003574..6006827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273191.1 → NP_001260120.1  beta galactosidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCA6
      Conserved Domains (2) summary
      pfam01301
      Location:52 → 374
      Glyco_hydro_35; Glycosyl hydrolases family 35
      pfam13364
      Location:568 → 635
      BetaGal_dom4_5; Beta-galactosidase jelly roll domain

    2. NM_135134.3 → NP_608978.2  beta galactosidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608978.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMJ5
      Related
      FBpp0078861
      Conserved Domains (2) summary
      pfam01301
      Location:54 → 376
      Glyco_hydro_35; Glycosyl hydrolases family 35
      pfam13364
      Location:570 → 637
      BetaGal_dom4_5; Beta-galactosidase jelly roll domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCA6 M9PCA6
    Q9VMJ5 Q9VMJ5

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