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    Lsp2 Larval serum protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsp2provided by FlyBase
    Official Full Name
    Larval serum protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0002565
    Locus tag
    Dmel_CG6806
    See related
    AllianceGenome:FB:FBgn0002565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C23; CG11538; CG6806; DmeLSP2; Dmel\CG6806; LHP; LSP 2; Lsp-2; LSP-2; lsp2; LSP2; Pt-1
    Summary
    Involved in motor neuron axon guidance and synaptic target inhibition. Part of larval serum protein complex. Is expressed in adult fat body; adult head; embryonic/larval fat body; and fat body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lsp2 in Genome Data Viewer
    Location:
    68F5-68F5; 3-38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12129393..12131869)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12122493..12124969)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 68b Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR11538 Neighboring gene antisense RNA:CR45892 Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of oligosaccharides from Drosophila melanogaster glycoproteins. Williams PJ, et al. Biochim Biophys Acta, 1991 Oct 10. PMID 1932070
    2. Drosophila hemolymph proteins: purification, characterization, and genetic mapping of larval serum protein 2 in D. melanogaster. Akam ME, et al. Biochem Genet, 1978 Feb. PMID 417715
    3. The Drosophila Lsp-1 beta gene. A structural and phylogenetic analysis. Massey HC Jr, et al. Eur J Biochem, 1997 Apr 1. PMID 9128742
    4. Protein Differences in Drosophila. I. Drosophila Melanogaster. Hubby JL. Genetics, 1963 Jun. PMID 17248176, Free PMC Article
    5. Overlapping Lsp-2 gene sequences target expression to both the larval and adult Drosophila fat body. Benes H, et al. Insect Mol Biol, 1996 Feb. PMID 8630534

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of larval serum protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    larval serum protein 2
    Names
    CG6806-PA
    CG6806-PB
    Lsp2-PA
    Lsp2-PB
    Protein-1
    larval serum protein-2
    larval-hemolymph-protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12129393..12131869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300113.1 → NP_001287042.1  larval serum protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287042.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24388, Q9VTT8
      UniProtKB/TrEMBL
      X2JCV2
      Conserved Domains (3) summary
      pfam00372
      Location:163 → 420
      Hemocyanin_M; Hemocyanin, copper containing domain
      pfam03722
      Location:33 → 156
      Hemocyanin_N; Hemocyanin, all-alpha domain
      pfam03723
      Location:430 → 693
      Hemocyanin_C; Hemocyanin, ig-like domain

    2. NM_080077.2 → NP_524816.1  larval serum protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524816.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24388, Q9VTT8
      UniProtKB/TrEMBL
      X2JCV2
      Related
      FBpp0088363, FBtr0089324
      Conserved Domains (3) summary
      pfam00372
      Location:163 → 420
      Hemocyanin_M; Hemocyanin, copper containing domain
      pfam03722
      Location:33 → 156
      Hemocyanin_N; Hemocyanin, all-alpha domain
      pfam03723
      Location:430 → 693
      Hemocyanin_C; Hemocyanin, ig-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24388.2 Q24388
    X2JCV2 X2JCV2

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