Cdc42ep4 CDC42 effector protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc42ep4provided by MGI
Official Full Name: CDC42 effector protein 4provided by MGI
Primary source: MGI:MGI:1929760
See related: Ensembl:ENSMUSG00000041598 AllianceGenome:MGI:1929760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CEP4; Borg4; 1500041M20Rik
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within Rho protein signal transduction and cellular response to type II interferon. Located in phagocytic vesicle. Is expressed in several structures, including central nervous system; forelimb bud; heart valve; lung; and retina. Orthologous to human CDC42EP4 (CDC42 effector protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 59.8), lung adult (RPKM 30.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 79.22 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (113617676..113643369, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (113726850..113752543, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of dendrite growth by Cdc42 effector protein4 in hippocampal neurons in vitro.
Title: Regulation of dendrite growth by Cdc42 effector protein‑4 in hippocampal neurons in vitro.
overexpression of CDC42EP4 in heterologous cells promotes cell spreading and partitioning of MYH10 to insoluble (i.e., active) fraction
Title: CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
This study suggests propose that the CDC42EP4/septin-based glial scaffold facilitates perisynaptic localization of GLAST and optimizes the efficiency of glutamate-buffering and clearance.
Title: A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pseudopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pseudopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cdc42 effector protein 4

Names: CDC42 effector protein (Rho GTPase binding) 4; binder of Rho GTPase 4; binder of Rho GTPases 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163346.1 → NP_001156818.1 cdc42 effector protein 4

See identical proteins and their annotated locations for NP_001156818.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AB035088, AK165318

Consensus CDS

CCDS25604.1

UniProtKB/Swiss-Prot

Q3TNF3, Q9JM96, Q9QZT8

UniProtKB/TrEMBL

Q3TH99

Related

ENSMUSP00000060227.5, ENSMUST00000053536.5

Conserved Domains (2) summary

pfam00786
Location:26 → 79

PBD; P21-Rho-binding domain

pfam14957
Location:110 → 219

BORG_CEP; Cdc42 effector
NM_020006.2 → NP_064390.1 cdc42 effector protein 4

See identical proteins and their annotated locations for NP_064390.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AB035088, AK075739, BM950172

Consensus CDS

CCDS25604.1

UniProtKB/Swiss-Prot

Q3TNF3, Q9JM96, Q9QZT8

UniProtKB/TrEMBL

Q3TH99

Related

ENSMUSP00000102227.2, ENSMUST00000106616.2

Conserved Domains (2) summary

pfam00786
Location:26 → 79

PBD; P21-Rho-binding domain

pfam14957
Location:110 → 219

BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

113617676..113643369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533815.2 → XP_006533878.1 cdc42 effector protein 4 isoform X1

UniProtKB/TrEMBL

Q3TH99

Conserved Domains (2) summary

pfam00786
Location:111 → 164

PBD; P21-Rho-binding domain

pfam14957
Location:195 → 304

BORG_CEP; Cdc42 effector
XM_006533817.3 → XP_006533880.1 cdc42 effector protein 4 isoform X2

See identical proteins and their annotated locations for XP_006533880.1

UniProtKB/Swiss-Prot

Q3TNF3, Q9JM96, Q9QZT8

UniProtKB/TrEMBL

Q3TH99

Conserved Domains (2) summary

pfam00786
Location:26 → 79

PBD; P21-Rho-binding domain

pfam14957
Location:110 → 219

BORG_CEP; Cdc42 effector
XM_017314686.3 → XP_017170175.1 cdc42 effector protein 4 isoform X2

UniProtKB/Swiss-Prot

Q3TNF3, Q9JM96, Q9QZT8

UniProtKB/TrEMBL

Q3TH99

Conserved Domains (2) summary

pfam00786
Location:26 → 79

PBD; P21-Rho-binding domain

pfam14957
Location:110 → 219

BORG_CEP; Cdc42 effector
XM_006533819.4 → XP_006533882.1 cdc42 effector protein 4 isoform X2

See identical proteins and their annotated locations for XP_006533882.1

UniProtKB/Swiss-Prot

Q3TNF3, Q9JM96, Q9QZT8

UniProtKB/TrEMBL

Q3TH99

Conserved Domains (2) summary

pfam00786
Location:26 → 79

PBD; P21-Rho-binding domain

pfam14957
Location:110 → 219

BORG_CEP; Cdc42 effector
XM_006533818.4 → XP_006533881.1 cdc42 effector protein 4 isoform X2

See identical proteins and their annotated locations for XP_006533881.1

UniProtKB/Swiss-Prot

Q3TNF3, Q9JM96, Q9QZT8

UniProtKB/TrEMBL

Q3TH99

Conserved Domains (2) summary

pfam00786
Location:26 → 79

PBD; P21-Rho-binding domain

pfam14957
Location:110 → 219

BORG_CEP; Cdc42 effector