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    CG8993 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8993provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035334
    Locus tag
    Dmel_CG8993
    See related
    AllianceGenome:FB:FBgn0035334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8993; Dmel\CG8993
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Predicted to be active in mitochondrion. Is expressed in adult heart and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8993 in Genome Data Viewer
    Location:
    62D7-62D7; 3-2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2372199..2372876)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2372199..2372876)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Supervillin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitotic spindle organizing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Svensson MJ, et al. Hereditas, 2007 Mar. PMID 17567437
    2. Characterization, design, and function of the mitochondrial proteome: from organs to organisms. Lotz C, et al. J Proteome Res, 2014 Feb 7. PMID 24070373, Free PMC Article
    3. A network of conserved damage survival pathways revealed by a genomic RNAi screen. Ravi D, et al. PLoS Genet, 2009 Jun. PMID 19543366, Free PMC Article
    4. A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye. Jasper H, et al. Dev Cell, 2002 Oct. PMID 12408803
    5. Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein. Chen L, et al. Genome Biol, 2014 Jan 7. PMID 24393533, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8993-PA
    thioredoxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2372199..2372876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139459.3 → NP_647716.1  uncharacterized protein Dmel_CG8993 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W022
      Related
      FBpp0072767
      Conserved Domains (1) summary
      cl00388
      Location:39 → 138
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W022 Q9W022

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