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    Lipt2 Lipoyl(octanoyl) transferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lipt2provided by FlyBase
    Official Full Name
    Lipoyl(octanoyl) transferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037251
    Locus tag
    Dmel_CG9804
    See related
    AllianceGenome:FB:FBgn0037251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9804; Dmel\CG9804
    Summary
    Predicted to enable lipoyl(octanoyl) transferase activity. Predicted to be involved in protein lipoylation. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to human LIPT2 (lipoyl(octanoyl) transferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lipt2 in Genome Data Viewer
    Location:
    82B1-82B1; 3-47.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4436222..4437329, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (261944..263051, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit a Neighboring gene antisense RNA:CR46138 Neighboring gene antisense RNA:CR44134 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43629

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Scramblases modulate synaptic transmission. Acharya U, et al. J Cell Biol, 2006 Apr 10. PMID 16606691, Free PMC Article
    2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
    3. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipoyl(octanoyl) transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoyl(octanoyl) transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipoyl(octanoyl) transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein lipoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein lipoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Lipoyl(octanoyl) transferase 2
    Names
    CG9804-PA
    CG9804-PB
    Lipt2-PA
    Lipt2-PB
    NP_001303459.1
    NP_649472.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4436222..4437329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141215.2 → NP_649472.1  Lipoyl(octanoyl) transferase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VN27
      UniProtKB/TrEMBL
      A0A126GUP4
      Related
      FBpp0078583, FBtr0078943
      Conserved Domains (1) summary
      cl14057
      Location:1 → 216
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    2. NM_001316530.1 → NP_001303459.1  Lipoyl(octanoyl) transferase 2, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VN27
      UniProtKB/TrEMBL
      A0A126GUP4
      Conserved Domains (1) summary
      cl14057
      Location:1 → 216
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUP4 A0A126GUP4
    Q9VN27.1 Q9VN27

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