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    secs-1 O-phosphoseryl-tRNA(Sec) selenium transferase [ Caenorhabditis elegans ]

    Gene ID: 179498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    secs-1
    Official Full Name
    O-phosphoseryl-tRNA(Sec) selenium transferase
    Primary source
    WormBase:WBGene00008379
    Locus tag
    CELE_D1054.13
    See related
    AllianceGenome:WB:WBGene00008379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Is expressed in head neurons and ventral nerve cord. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See secs-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (10802336..10804474, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Pre-mRNA-splicing factor 38 Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    2. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-phosphoseryl-tRNA(Sec) selenium transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O-phosphoseryl-tRNA(Sec) selenium transferase
    NP_001129887.1
    • Confirmed by transcript evidence
    NP_505761.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10802336..10804474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073360.4 → NP_505761.1  O-phosphoseryl-tRNA(Sec) selenium transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5U8M4, Q18953
      Conserved Domains (1) summary
      TIGR03531
      Location:4 → 449
      selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

    2. NM_001136415.3 → NP_001129887.1  O-phosphoseryl-tRNA(Sec) selenium transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129887.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18953
      Conserved Domains (1) summary
      TIGR03531
      Location:46 → 491
      selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18953.1

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