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    T13H5.1 Receptor-type tyrosine-protein phosphatase kappa;Receptor-type tyrosine-protein phosphatase mu;Tyrosine-protein phosphatase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T13H5.1
    Official Full Name
    Receptor-type tyrosine-protein phosphatase kappa;Receptor-type tyrosine-protein phosphatase mu;Tyrosine-protein phosphatase domain-containing protein
    Primary source
    WormBase:WBGene00011755
    Locus tag
    CELE_T13H5.1
    See related
    AllianceGenome:WB:WBGene00011755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction and synaptic membrane adhesion. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A) and PTPRE (protein tyrosine phosphatase receptor type E). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T13H5.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    28
    Sequence:
    Chromosome: II; NC_003280.10 (8487513..8509056, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene HIG1 domain-containing protein Neighboring gene TAil-Anchored Protein Neighboring gene Trimethyllysine dioxygenase, mitochondrial Neighboring gene ncRNA Neighboring gene DB domain-containing protein Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene Ribonuclease H2 subunit A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type tyrosine-protein phosphatase kappa;Receptor-type tyrosine-protein phosphatase mu;Tyrosine-protein phosphatase domain-containing protein
    NP_001022346.2
    • Confirmed by transcript evidence
    NP_001022347.1
    • Confirmed by transcript evidence
    NP_001122640.1
    • Confirmed by transcript evidence
    NP_001129824.1
    • Confirmed by transcript evidence
    NP_001129825.1
    • Partially confirmed by transcript evidence
    NP_001254153.1
    • Confirmed by transcript evidence
    NP_001254154.1
    • Confirmed by transcript evidence
    NP_001254155.1
    • Confirmed by transcript evidence
    NP_001379493.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8487513..8509056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027175.4 → NP_001022346.2  Receptor-type tyrosine-protein phosphatase kappa [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022346.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGI0
      Conserved Domains (2) summary
      smart00194
      Location:206 → 465
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:233 → 465
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001136352.5 → NP_001129824.1  Receptor-type tyrosine-protein phosphatase kappa [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGJ3
      Conserved Domains (2) summary
      smart00194
      Location:93 → 352
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:120 → 352
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. NM_001136353.3 → NP_001129825.1  Receptor-type tyrosine-protein phosphatase mu [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129825.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGM6
      Conserved Domains (2) summary
      smart00194
      Location:66 → 325
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:93 → 325
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    4. NM_001129168.4 → NP_001122640.1  Receptor-type tyrosine-protein phosphatase kappa [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC69
      Conserved Domains (3) summary
      smart00194
      Location:206 → 465
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:233 → 465
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cl21483
      Location:528 → 796
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    5. NM_001267225.3 → NP_001254154.1  Receptor-type tyrosine-protein phosphatase kappa [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECI6
      Conserved Domains (2) summary
      smart00194
      Location:162 → 421
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:189 → 421
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    6. NM_001393137.1 → NP_001379493.1  Receptor-type tyrosine-protein phosphatase kappa [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEM4
      Conserved Domains (1) summary
      smart00194
      Location:155 → 414
      PTPc; Protein tyrosine phosphatase, catalytic domain

    7. NM_001267226.3 → NP_001254155.1  Receptor-type tyrosine-protein phosphatase mu [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG42
      Conserved Domains (2) summary
      smart00194
      Location:57 → 316
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:84 → 316
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    8. NM_001027176.5 → NP_001022347.1  Receptor-type tyrosine-protein phosphatase kappa [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFE8
      Conserved Domains (2) summary
      smart00194
      Location:114 → 373
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:141 → 373
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    9. NM_001267224.3 → NP_001254153.1  Tyrosine-protein phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU90
      Conserved Domains (1) summary
      cl21483
      Location:25 → 127
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
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