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    lec-8 putative galaptin lec-8 [ Caenorhabditis elegans ]

    Gene ID: 181198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lec-8
    Official Full Name
    putative galaptin lec-8
    Primary source
    WormBase:WBGene00002271
    Locus tag
    CELE_R07B1.10
    See related
    AllianceGenome:WB:WBGene00002271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables glycolipid binding activity. Involved in response to toxic substance. Located in cytoplasmic vesicle. Is expressed in intestine; pharyngeal-intestinal valve; tail; virL; and virR. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lec-8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (9850571..9851336)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeobox protein vab-15 Neighboring gene putative galaptin lec-7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pre-feeding of a glycolipid binding protein LEC-8 from Caenorhabditis elegans revealed enhanced tolerance to Cry1Ac toxin in Helicoverpa armigera. Ma G, et al. Results Immunol, 2012. PMID 24371572, Free PMC Article
    2. The DC2.3 gene in Caenorhabditis elegans encodes a galectin that recognizes the galactoseβ1→4fucose disaccharide unit. Nemoto-Sasaki Y, et al. Biol Pharm Bull, 2011. PMID 21963509
    3. Paralysis of nematodes: shifts in the transcriptome of the nematode-trapping fungus Monacrosporium haptotylum during infection of Caenorhabditis elegans. Fekete C, et al. Environ Microbiol, 2008 Feb. PMID 18028414
    4. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
    5. A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Ideo H, et al. J Biol Chem, 2009 Sep 25. PMID 19635802, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycolipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in defense response to Gram-positive bacterium IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative galaptin lec-8
    NP_509649.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9850571..9851336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077248.6 → NP_509649.1  putative galaptin lec-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09610, Q9GNP9
      Conserved Domains (1) summary
      smart00276
      Location:14 → 138
      GLECT; Galectin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09610.2

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