SEMA3C semaphorin 3C [Gallus gallus (chicken)] - Gene

Summary

Symbol: SEMA3Cprovided by CGNC
Full Name: semaphorin 3Cprovided by CGNC
Primary source: CGNC:49039
See related: Ensembl:ENSGALG00010010460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: semaphorin-3C
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (11250327..11372449)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (11383302..11505859)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of the motoneuronal Sema3 code could be to set population-specific axon sensitivity to limb-derived chemotropic Sema3 proteins, therefore specifying stereotyped motor nerve trajectories in their target field.
Title: Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info	PubMed
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: semaphorin-3C

Names: COLL-3; collapsin-3; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204243.2 → NP_989574.2 semaphorin-3C precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

O42236, Q90664

UniProtKB/TrEMBL

A0A1D5PZ68

Related

ENSGALP00010014213.1, ENSGALT00010025009.1

Conserved Domains (3) summary

cd11251
Location:45 → 514

Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)

smart00423
Location:513 → 550

PSI; domain found in Plexins, Semaphorins and Integrins

cd05871
Location:574 → 664

Ig_Sema3; Immunoglobulin (Ig)-like domain of class III semaphorin Sema3