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    semialdehyde dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838046, updated on 18-Sep-2024

    Summary

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    Official Full Name
    semialdehyde dehydrogenase family protein
    Primary source
    TAIR:AT1G14810
    Locus tag
    AT1G14810
    See related
    Araport:AT1G14810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F10B6.22; F10B6_22
    Summary
    encodes an aspartate semialdehyde dehydrogenase, which produces the branch point intermediate for lysine and threonine/methionine biosynthesis
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (5102424..5104850, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene MAC/Perforin domain-containing protein Neighboring gene RNA-dependent RNA polymerase 1 Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene ncRNA Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene DYNAMIN-like 1C Neighboring gene microtubule-associated proteins 70-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overproduction, purification, and characterization of recombinant aspartate semialdehyde dehydrogenase from Arabidopsis thaliana. Paris S, et al. Protein Expr Purif, 2002 Feb. PMID 11812229
    2. Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana. Lampugnani ER, et al. PLoS One, 2024. PMID 38358988, Free PMC Article
    3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332137.1
    NM_101350.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    semialdehyde dehydrogenase family protein
    NP_172934.1
    • semialdehyde dehydrogenase family protein; FUNCTIONS IN: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, aspartate-semialdehyde dehydrogenase activity; INVOLVED IN: cellular amino acid biosynthetic process, oxidation reduction, threonine biosynthetic process, methionine biosynthetic process, cellular amino acid metabolic process; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Semialdehyde dehydrogenase, dimerisation domain (InterPro:IPR012280), Semialdehyde dehydrogenase, NAD-binding (InterPro:IPR000534), Aspartate-semialdehyde dehydrogenase, bacterial (InterPro:IPR005986), Aspartate-semialdehyde dehydrogenase (InterPro:IPR012080); Has 10268 Blast hits to 10266 proteins in 2514 species: Archae - 260; Bacteria - 6386; Metazoa - 3; Fungi - 175; Plants - 61; Viruses - 0; Other Eukaryotes - 3383 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5102424..5104850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101350.4 → NP_172934.1  semialdehyde dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W3P2, Q8VYI4, Q9FVC4
      Conserved Domains (1) summary
      PLN02383
      Location:32 → 375
      PLN02383; aspartate semialdehyde dehydrogenase

    2. NM_001332137.1 → NP_001320803.1  semialdehyde dehydrogenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ANY1
    Nucleotide Protein
    Heading Accession and Version

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