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    CG11162 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11162provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030509
    Locus tag
    Dmel_CG11162
    See related
    AllianceGenome:FB:FBgn0030509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11162
    Summary
    Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11162 in Genome Data Viewer
    Location:
    12B2-12B2; 1-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13676894..13677882)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13570927..13571915)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NAD synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson's disease. Cesur MF, et al. Life Sci Alliance, 2023 Aug. PMID 37236669, Free PMC Article
    2. Drosophila lacks C20 and C22 PUFAs. Shen LR, et al. J Lipid Res, 2010 Oct. PMID 20656917, Free PMC Article
    3. High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis. Sridharan V, et al. PLoS One, 2016. PMID 26942929, Free PMC Article
    4. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    5. Fat body-specific reduction of CTPS alleviates HFD-induced obesity. Liu J, et al. Elife, 2023 Sep 11. PMID 37695169, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11162-PA
    NP_572910.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13676894..13677882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132682.2 → NP_572910.1  uncharacterized protein Dmel_CG11162 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYA2
      Related
      FBpp0073642
      Conserved Domains (2) summary
      COG3000
      Location:31 → 269
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:131 → 256
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYA2 Q9VYA2

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