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    huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Haplochromis burtoni (Burton's mouthbrooder) ]

    Gene ID: 102300144, updated on 10-Mar-2024

    Summary

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    Gene symbol
    huwe1
    Gene description
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
    See related
    Ensembl:ENSHBUG00000002965
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Haplochromis burtoni
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Haplochromis
    Orthologs
    human zebrafish all
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    Genomic context

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    See huwe1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    85
    Annotation release Status Assembly Chr Location
    102 current NCSU_Asbu1 (GCF_018398535.1) Unplaced Scaffold NW_024582370.1 (2715595..2767447, complement)
    101 previous assembly AstBur1.0 (GCF_000239415.1) Unplaced Scaffold NW_005179408.1 (2709992..2761527, complement)

    NW_024582370.1Genomic Context describing neighboring genes Neighboring gene RIB43A domain with coiled-coils 1 Neighboring gene L1 cell adhesion molecule, paralog a Neighboring gene PHD finger protein 8 Neighboring gene WNK lysine deficient protein kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Haplochromis burtoni Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NCSU_Asbu1 Primary Assembly

    Genomic

    1. NW_024582370.1 Reference NCSU_Asbu1 Primary Assembly

      Range
      2715595..2767447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042227874.1 → XP_042083808.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1692 → 1753
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3613 → 3720
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2903 → 3144
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4198 → 4551
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1392 → 1431
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    2. XM_042227867.1 → XP_042083801.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1692 → 1753
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3630 → 3737
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2832 → 3161
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4219 → 4572
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1392 → 1431
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    3. XM_042227860.1 → XP_042083794.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1697 → 1758
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3635 → 3742
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2837 → 3166
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4224 → 4577
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1397 → 1436
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    4. XM_042227862.1 → XP_042083796.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3633 → 3740
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2835 → 3164
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4222 → 4575
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    5. XM_042227872.1 → XP_042083806.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3619 → 3726
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2909 → 3150
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4208 → 4561
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    6. XM_014339303.2 → XP_014194789.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (7) summary
      smart00119
      Location:4248 → 4576
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4224 → 4577
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:90 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 853
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3066 → 3178
      DUF4414; Domain of unknown function (DUF4414)

    7. XM_042227865.1 → XP_042083799.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4221 → 4574
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    8. XM_042227873.1 → XP_042083807.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4174 → 4527
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    9. XM_042227839.1 → XP_042083773.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    10. XM_042227847.1 → XP_042083781.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    11. XM_042227840.1 → XP_042083774.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    12. XM_042227842.1 → XP_042083776.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    13. XM_042227850.1 → XP_042083784.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    14. XM_042227845.1 → XP_042083779.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins

    15. XM_042227855.1 → XP_042083789.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q3BL04
      Conserved Domains (5) summary
      smart00678
      Location:1698 → 1759
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03255
      Location:3636 → 3743
      PHA03255; BDLF3; Provisional
      PHA03247
      Location:2838 → 3167
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4225 → 4578
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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