Mycbpap Mycbp associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mycbpapprovided by RGD
Full Name: Mycbp associated proteinprovided by RGD
Primary source: RGD:1359123
See related: EnsemblRapid:ENSRNOG00000042912 AllianceGenome:RGD:1359123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COD106
Summary: Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in chemical synaptic transmission. Predicted to be located in cytoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Orthologous to human MYCBPAP (MYCBP associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 99.6), Heart (RPKM 73.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (79947200..79967857, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79450319..79470977, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82232105..82253649, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cod106 is expressed in auditory and vestibular hair cells, as well as in distinct sets of CNS neurons with particularly high abundance in hippocampus and cerebellum.(Cod106)
Title: Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_16741-16742:1020435796:1 (e-PCR)
- UniSTS:268095

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MYCBP-associated protein

Names: cochlea derived protein of 106 kDa; organ of Corti membrane-associated protein of 106 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009482.2 → NP_001009482.2 MYCBP-associated protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K1H9
NM_001395044.2 → NP_001381973.1 MYCBP-associated protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q69CM6, Q69CM7

Related

ENSRNOP00000071847.3, ENSRNOT00000086261.3
NM_001415761.1 → NP_001402690.1 MYCBP-associated protein isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

F1LPD4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

79947200..79967857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086538.2 → XP_038942466.1 MYCBP-associated protein isoform X5

UniProtKB/TrEMBL

A0A0G2K1H9

Conserved Domains (1) summary

pfam14646
Location:187 → 602

MYCBPAP; MYCBP-associated protein family
XM_039086534.2 → XP_038942462.1 MYCBP-associated protein isoform X1

UniProtKB/Swiss-Prot

Q69CM6, Q69CM7

Related

ENSRNOP00000107004.1, ENSRNOT00000125400.1

Conserved Domains (1) summary

pfam14646
Location:279 → 694

MYCBPAP; MYCBP-associated protein family
XM_039086536.2 → XP_038942464.1 MYCBP-associated protein isoform X4

UniProtKB/Swiss-Prot

Q69CM6, Q69CM7

Related

ENSRNOP00000062686.4, ENSRNOT00000066132.5

Conserved Domains (1) summary

pfam14646
Location:195 → 610

MYCBPAP; MYCBP-associated protein family
XM_063269578.1 → XP_063125648.1 MYCBP-associated protein isoform X2
XM_063269579.1 → XP_063125649.1 MYCBP-associated protein isoform X3

UniProtKB/TrEMBL

M0RBQ9

Related

ENSRNOP00000067004.2, ENSRNOT00000075795.5