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    CtsK1 Cathepsin K1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsK1provided by FlyBase
    Official Full Name
    Cathepsin K1provided by FlyBase
    Primary source
    FLYBASE:FBgn0250848
    Locus tag
    Dmel_CG8947
    See related
    AllianceGenome:FB:FBgn0250848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    26-29-p; 26/29kD-proteinase; anon-SAGE:Wang-123; CG8947; Cts6; CTSK; Dmel\CG8947; l(3)s3635
    Summary
    Enables cysteine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade and zymogen activation. Is active in extracellular space. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsK1 in Genome Data Viewer
    Location:
    70C10-70C10; 3-41 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13994231..13996571)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13987331..13989671)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nitrogen permease regulator-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two subunits of the insect 26/29-kDa proteinase are probably derived from a common precursor protein. Fujimoto Y, et al. J Biochem, 1999 Mar. PMID 10050046
    2. Cp1/cathepsin L is required for autolysosomal clearance in Drosophila. Xu T, et al. Autophagy, 2021 Oct. PMID 33112206, Free PMC Article
    3. Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar S, et al. J Biomol Struct Dyn, 2013 Dec. PMID 23256878
    4. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Kawasaki H, et al. Gene, 2017 May 30. PMID 28286087
    5. The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway. Issa N, et al. Mol Cell, 2018 Feb 15. PMID 29452635, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zymogen activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin K1
    Names
    26,29kDa proteinase
    26-29 kD-proteinase
    26-29-protease
    26-29kD-proteinase
    26-29kDa proteinase
    26-29kd prot
    CG8947-PA
    CtsK1-PA
    anon-SAGE:Wang-123
    cathepsin K
    NP_620470.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13994231..13996571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138985.3 → NP_620470.1  cathepsin K1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3U6
      Related
      FBpp0075508
      Conserved Domains (2) summary
      smart00848
      Location:245 → 300
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:331 → 547
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3U6 Q9V3U6

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