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    bves bves [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bvesprovided by FlyBase
    Official Full Name
    bvesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031150
    Locus tag
    Dmel_CG32513
    See related
    AllianceGenome:FB:FBgn0031150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD21670; CG1544; CG15448; CG1754; CG32513; Dmel\CG32513
    Summary
    Predicted to enable cAMP binding activity. Predicted to be involved in several processes, including cell-cell adhesion; heart development; and striated muscle cell differentiation. Predicted to be located in membrane. Predicted to be active in sarcolemma. Is expressed in adult head; follicle cell; and nurse cell. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy and autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to several human genes including BVES (blood vessel epicardial substance). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bves in Genome Data Viewer
    Location:
    19E7-19E8; 1-65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21053963..21082391)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20924990..20953418)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene small Cajal body-specific RNA : MeU2-C28 Neighboring gene Catalytic subunit 3A of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stargazin-like protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling. Lin S, et al. Int J Dev Biol, 2007. PMID 17183463
    2. Partial loss of GATA factor Pannier impairs adult heart function in Drosophila. Qian L, et al. Hum Mol Genet, 2009 Sep 1. PMID 19494035, Free PMC Article
    3. Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline. Mohr C, et al. Sex Dev, 2017. PMID 28273663
    4. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Kong EC, et al. Alcohol Clin Exp Res, 2010 Feb. PMID 19951294, Free PMC Article
    5. Drosophila models to study causative genes for human rare intractable neurological diseases. Yamaguchi M, et al. Exp Cell Res, 2021 Jun 1. PMID 33812867

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that the repression of bves expression in anterior-dorsal follicle cells is regulated by the Grk/EGFR signalling pathway.
      Title: Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in striated muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bves
    Names
    CG32513-PA
    CG32513-PB
    CG32513-PC
    CG32513-PD
    bves-PA
    bves-PB
    bves-PC
    bves-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21053963..21082391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134582.4 → NP_608426.1  bves, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTX4, Q9VRE2
      Related
      FBpp0076939
      Conserved Domains (1) summary
      pfam04831
      Location:98 → 320
      Popeye; Popeye protein conserved region

    2. NM_001272823.1 → NP_001259752.1  bves, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H830
      Conserved Domains (1) summary
      pfam04831
      Location:98 → 320
      Popeye; Popeye protein conserved region

    3. NM_001272824.1 → NP_001259753.1  bves, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJS1
      Conserved Domains (1) summary
      pfam04831
      Location:98 → 320
      Popeye; Popeye protein conserved region

    4. NM_206800.3 → NP_996523.1  bves, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTX4, Q9VRE2
      Conserved Domains (1) summary
      pfam04831
      Location:98 → 320
      Popeye; Popeye protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G7H830 G7H830
    M9PJS1 M9PJS1
    Q8MRV2 Q8MRV2
    Q9VRE2 Q9VRE2

    Gene LinkOut

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