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    Slc35a2 solute carrier family 35 member A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100158233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc35a2provided by RGD
    Official Full Name
    solute carrier family 35 member A2provided by RGD
    Primary source
    RGD:2293497
    See related
    EnsemblRapid:ENSRNOG00000024801 AllianceGenome:RGD:2293497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable UDP-galactose transmembrane transporter activity. Predicted to be involved in UDP-galactose transmembrane transport. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 64.4), Kidney (RPKM 62.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc35a2 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17280072..17288928, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14608145..14616937, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15453184..15461990, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene polyglutamine binding protein 1 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene OTU deubiquitinase 5 Neighboring gene solute carrier family 25 member 39, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants. Ishida N, et al. J Biochem, 1999 Dec. PMID 10578063
    2. Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters. Maszczak-Seneczko D, et al. Acta Biochim Pol, 2011. PMID 21918738
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188623

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within UDP-galactose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-galactose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-galactose translocator
    Names
    solute carrier family 35 (UDP-galactose transporter), member A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127642.2 → NP_001121114.2  UDP-galactose translocator

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5Y5Y5, A6KP68, B2RYK5, F7FFH4
      Related
      ENSRNOP00000079603.1, ENSRNOT00000096381.2
      Conserved Domains (1) summary
      pfam04142
      Location:31 → 339
      Nuc_sug_transp; Nucleotide-sugar transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17280072..17288928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099384.2 → XP_038955312.1  UDP-galactose translocator isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y5Y5, B2RYK5
      Conserved Domains (1) summary
      pfam04142
      Location:31 → 367
      Nuc_sug_transp; Nucleotide-sugar transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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