Rheb Ras homolog enriched in brain [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rhebprovided by FlyBase
Official Full Name: Ras homolog enriched in brainprovided by FlyBase
Primary source: FLYBASE:FBgn0041191
Locus tag: Dmel_CG1081
See related: AllianceGenome:FB:FBgn0041191
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1081; Dm Rheb; Dmel\CG1081; DmRheb; DReb; dRheb; Q9VND8; rheb; RheB; RHEB
Summary: Enables GTPase activity. Involved in several processes, including positive regulation of nervous system development; regulation of TOR signaling; and regulation of macroautophagy. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; medullary zone of lymph gland primary lobe; and organism. Used to study disease of metabolism; tuberous sclerosis; and type 2 diabetes mellitus. Orthologous to several human genes including RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83B2-83B2; 3-47.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5568921..5570491)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1394643..1396213)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rheb overexpression in the central brain neurons of flies causes not only morphological phenotypes, but behavioral and aging phenotypes that may mirror symptoms of tuberous sclerosis complex
Title: The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
Drosophila TCTP (dTCTP) displays GEF activity to Rheb and is essential for Rheb activation in organ growth
Title: To cease or to proliferate: new insights into TCTP function from a Drosophila study.
Results suggest that TSC1/2 and Rheb have different effects on the activity of TORC1 and -2, further supporting the complexity of TOR regulation.
Title: TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
Rheb is a direct target of the tuberous sclerosis suppressor proteins.
Title: Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
dRheb is required for both cell growth (increase in mass) and cell cycle progression
Title: Drosophila Rheb GTPase is required for cell cycle progression and cell growth.
Results show that mildly increasing systemic Rheb-TOR-S6K signaling sensitizes the whole organism to oxidative stress and promotes senescence of locomotor activity with age.
Title: Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress.
Rheb-TOR signaling controls S2 cell growth by promoting ribosome production and protein synthesis, not by direct effects on the import of amino acids or glucose.
Title: Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila.
Our studies identify TCTP as a direct regulator of Rheb and a potential therapeutic target for tuberous sclerosis disease.
Title: Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.
Rheb promotes cell growth as a component of the insulin/TOR signaling network.
Title: Rheb promotes cell growth as a component of the insulin/TOR signalling network.
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
Title: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of TORC2 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ras homolog enriched in brain

Names: CG1081-PA; CG1081-PB; RAS homolog enriched in brain; Ras homolog enriched in brain ortholog; Ras homologue enriched in brain; Ras homology enriched in brain; Rheb-PA; Rheb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5568921..5570491

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169068.3 → NP_730950.2 Ras homolog enriched in brain, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730950.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KIB7, Q9VND8

UniProtKB/TrEMBL

H1ZYG4

Related

FBpp0078342

Conserved Domains (1) summary

cd04137
Location:5 → 182

RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase
NM_169069.3 → NP_730951.2 Ras homolog enriched in brain, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730951.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KIB7, Q9VND8

UniProtKB/TrEMBL

H1ZYG4

Related

FBpp0078343

Conserved Domains (1) summary

cd04137
Location:5 → 182

RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase