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    CKX3 cytokinin oxidase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835799, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CKX3
    Official Full Name
    cytokinin oxidase 3
    Primary source
    TAIR:AT5G56970
    Locus tag
    AT5G56970
    See related
    Araport:AT5G56970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCKX3; CYTOKININ OXIDASE; cytokinin oxidase 3; MHM17.8; MHM17_8
    Summary
    It encodes a protein whose sequence is similar to cytokinin oxidase/dehydrogenase, which catalyzes the degradation of cytokinins.
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    Genomic context

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    See CKX3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (23044839..23048292, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1;3 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KNOX action in Arabidopsis is mediated by coordinate regulation of cytokinin and gibberellin activities. Jasinski S, et al. Curr Biol, 2005 Sep 6. PMID 16139211
    2. Reticulate leaves and stunted roots are independent phenotypes pointing at opposite roles of the phosphoenolpyruvate/phosphate translocator defective in cue1 in the plastids of both organs. Staehr P, et al. Front Plant Sci, 2014. PMID 24782872, Free PMC Article
    3. Cytokinin regulates the activity of reproductive meristems, flower organ size, ovule formation, and thus seed yield in Arabidopsis thaliana. Bartrina I, et al. Plant Cell, 2011 Jan. PMID 21224426, Free PMC Article
    4. Vacuolar and cytosolic cytokinin dehydrogenases of Arabidopsis thaliana: heterologous expression, purification and properties. Kowalska M, et al. Phytochemistry, 2010 Dec. PMID 20825956
    5. Molecular and biochemical characterization of a cytokinin oxidase from maize. Bilyeu KD, et al. Plant Physiol, 2001 Jan. PMID 11154345, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that boundary-expressing HAN communicates with the meristem through the PNH, regulates floral organ development via JAG and BOP2, and maintains boundary morphology through CKX3 during flower development in Arabidopsis
      Title: HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis.
    2. ckx3 ckx5 mutants form more silques and seeds, and regulate the activity of the reproductive meristems.
      Title: Cytokinin regulates the activity of reproductive meristems, flower organ size, ovule formation, and thus seed yield in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001345226.1
    NM_125079.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokinin dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokinin dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokinin dehydrogenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables primary methylamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cytokinin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytokinin oxidase 3
    NP_200507.1
    • cytokinin oxidase 3 (CKX3); FUNCTIONS IN: primary amine oxidase activity, cytokinin dehydrogenase activity; INVOLVED IN: cytokinin catabolic process; LOCATED IN: vacuole; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cytokinin dehydrogenase 1, FAD/cytokinin binding domain (InterPro:IPR015345), FAD-binding, type 2 (InterPro:IPR016166), Oxygen oxidoreductase covalent FAD-binding site (InterPro:IPR006093), FAD-linked oxidase-like, C-terminal (InterPro:IPR016164), FAD linked oxidase, N-terminal (InterPro:IPR006094); BEST Arabidopsis thaliana protein match is: cytokinin oxidase 4 (TAIR:AT4G29740.2); Has 7950 Blast hits to 7944 proteins in 1387 species: Archae - 176; Bacteria - 4485; Metazoa - 150; Fungi - 1601; Plants - 789; Viruses - 0; Other Eukaryotes - 749 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23044839..23048292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125079.3 → NP_200507.1  cytokinin oxidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTS3
      UniProtKB/TrEMBL
      A0A5S9YF90, B3DNN3
      Conserved Domains (3) summary
      PLN02441
      Location:4 → 523
      PLN02441; cytokinin dehydrogenase
      pfam01565
      Location:70 → 212
      FAD_binding_4; FAD binding domain
      pfam09265
      Location:244 → 517
      Cytokin-bind; Cytokinin dehydrogenase 1, FAD and cytokinin binding

    2. NM_001345226.1 → NP_001331716.1  cytokinin oxidase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BER3, A0A654GBX8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTS3.1

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