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    Topors Topoisomerase I-interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Toporsprovided by FlyBase
    Official Full Name
    Topoisomerase I-interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267351
    Locus tag
    Dmel_CG15104
    See related
    AllianceGenome:FB:FBgn0267351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15104; Dmel\CG15104; dtopors; dTopors; nbl; TOPORS
    Summary
    Enables lamin binding activity and ubiquitin protein ligase activity. Involved in several processes, including centrosome separation; male meiosis chromosome segregation; and meiotic chromosome condensation. Located in nuclear lamina and polytene chromosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Topors in Genome Data Viewer
    Location:
    56A2-56A2; 2-87 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18972612..18977262)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14860117..14864767)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene proliferation disrupter Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene thin Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors. Matsui M, et al. Genetics, 2011 Nov. PMID 21900273, Free PMC Article
    2. Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Vogelmann J, et al. Nucleus, 2011 Sep-Oct. PMID 21983085, Free PMC Article
    3. The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Capelson M, et al. Mol Cell, 2005 Oct 7. PMID 16209949
    4. SUMO conjugation attenuates the activity of the gypsy chromatin insulator. Capelson M, et al. EMBO J, 2006 May 3. PMID 16628226, Free PMC Article
    5. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein. Secombe J, et al. J Biol Chem, 2004 Apr 23. PMID 14871887

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission
      Title: Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.
    2. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein
      Title: Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    topoisomerase I-interacting protein
    Names
    CG15104-PA
    CG15104-PB
    Topors-PA
    Topors-PB
    nuclear blebber

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18972612..18977262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274154.1 → NP_001261083.1  topoisomerase I-interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261083.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V8P9
      UniProtKB/TrEMBL
      A0A0B4KEZ9
      Conserved Domains (1) summary
      cd00162
      Location:102 → 144
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_137544.3 → NP_611388.1  topoisomerase I-interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V8P9
      UniProtKB/TrEMBL
      A0A0B4KEZ9
      Related
      FBpp0085754
      Conserved Domains (1) summary
      cd00162
      Location:102 → 144
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEZ9 A0A0B4KEZ9
    Q9V8P9.1 Q9V8P9

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