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    PLCE1 phospholipase C epsilon 1 [ Hirundo rustica (Barn swallow) ]

    Gene ID: 120755579, updated on 3-Aug-2024

    Summary

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    Gene symbol
    PLCE1
    Gene description
    phospholipase C epsilon 1
    See related
    EnsemblRapid:ENSHRRG00010001878
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Hirundo rustica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Passeriformes; Sylvioidea; Hirundinidae; Hirundo
    Orthologs
    human mouse all
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    Genomic context

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    See PLCE1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_07 current bHirRus1.pri.v3 (GCF_015227805.2) 8 NC_053457.1 (19822857..19962105, complement)

    Chromosome 8 - NC_053457.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 12 Neighboring gene NOC3 like DNA replication regulator Neighboring gene solute carrier family 35 member G1 Neighboring gene protein FRA10AC1 Neighboring gene leucine rich glioma inactivated 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_053457.1 Chromosome 8 Reference bHirRus1.pri.v3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_015227805.2-RS_2023_07

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bHirRus1.pri.v3

    Genomic

    1. NC_053457.1 Reference bHirRus1.pri.v3

      Range
      19822857..19962105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040070697.2 → XP_039926631.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      UniProtKB/TrEMBL
      A0A7L4EMM4
      Related
      ENSHRRP00010002632.1, ENSHRRT00010002777.2
      Conserved Domains (6) summary
      cd00275
      Location:1884 → 2000
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1409 → 1849
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      cd16203
      Location:1215 → 1395
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:2151 → 2253
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cd17229
      Location:2023 → 2130
      RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cl02485
      Location:549 → 731
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. XM_040070695.2 → XP_039926629.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A7L4EMM4
      Related
      ENSHRRP00010002571.1, ENSHRRT00010002710.2
      Conserved Domains (6) summary
      cd00275
      Location:1898 → 2014
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1423 → 1863
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      cd16203
      Location:1229 → 1409
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:2165 → 2267
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cd17229
      Location:2037 → 2144
      RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cl02485
      Location:549 → 731
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    Nucleotide Protein
    Heading Accession and Version

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