SMC2 Structural maintenance of chromosomes 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SMC2provided by FlyBase
Official Full Name: Structural maintenance of chromosomes 2provided by FlyBase
Primary source: FLYBASE:FBgn0027783
Locus tag: Dmel_CG10212
See related: AllianceGenome:FB:FBgn0027783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF58197; CG10212; Dmel\CG10212; DmSMC2; dSMC2; smc-2; Smc2
Summary: Predicted to enable chromatin binding activity and protein heterodimerization activity. Predicted to contribute to ATP hydrolysis activity. Involved in chromosome condensation and regulation of stem cell differentiation. Located in chromatin and cytoplasm. Part of condensin complex. Colocalizes with condensed chromosome. Is expressed in several structures, including CNS glial cell; antennal primordium; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14848621..14852653, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10736126..10740158, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
contributes_to ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	NAS Non-traceable Author Statement more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
colocalizes_with condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

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