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    stj straightjacket [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36526, updated on 17-Dec-2024

    Summary

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    Official Symbol
    stjprovided by FlyBase
    Official Full Name
    straightjacketprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261041
    Locus tag
    Dmel_CG12295
    See related
    AllianceGenome:FB:FBgn0261041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha2delta; alpha[[2]]delta; alpha[[2]]delta-3; CG12295; dalpha[[2]]delta-3; dalpha[[2]]delta[[3]]; Dmel\CG12295; l(2)k10814
    Summary
    Predicted to enable voltage-gated calcium channel activity. Involved in several processes, including bulk synaptic vesicle endocytosis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of synaptic assembly at neuromuscular junction. Located in presynaptic active zone. Is expressed in several structures, including adult brain; adult head; adult optic lobe; embryonic/larval salivary gland; and ganglia. Used to study heart conduction disease. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stj in Genome Data Viewer
    Location:
    50C5-50C6; 2-68 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13805794..13819571)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9693299..9707076)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43811 Neighboring gene Cuticular protein 50Cb Neighboring gene female lethal d Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection. Yu Y, et al. PLoS Genet, 2016 Jul. PMID 27467689, Free PMC Article
    2. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. Dickman DK, et al. J Neurosci, 2008 Jan 2. PMID 18171920, Free PMC Article
    3. Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity. Zhang Y, et al. Front Mol Neurosci, 2023. PMID 38025261, Free PMC Article
    4. Different functions of two putative Drosophila α(2)δ subunits in the same identified motoneurons. Heinrich L, et al. Sci Rep, 2020 Aug 13. PMID 32792569, Free PMC Article
    5. Regulation of presynaptic Ca(2+) channel abundance at active zones through a balance of delivery and turnover. Cunningham KL, et al. Elife, 2022 Jul 14. PMID 35833625, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Different functions of two putative Drosophila alpha2delta subunits in the same identified motoneurons.
      Title: Different functions of two putative Drosophila α(2)δ subunits in the same identified motoneurons.
    2. stj is required in peripheral ppk+ sensory neurons for acute thermal responses and it mediates nociceptive hypersensitivity in an adult Drosophila model of neuropathic pain-like disease.
      Title: Peripheral straightjacket (α2δ Ca(2+) channel subunit) expression is required for neuropathic sensitization in Drosophila.
    3. stj is required for noxious heat avoidance in adult Drosophila
      Title: A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.
    4. In a screen for genes affecting synaptic function, straightjacket (stj), which encodes a Drosophila melanogaster alpha2delta similar to vertebrate alpha2delta3; stj mutants exhibit a severe reduction in Ca2+-dependent evoked neurotransmitter release.
      Title: straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bulk synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    straightjacket
    Names
    CG12295-PB
    CG12295-PC
    CG12295-PD
    lethal (2) k10814
    stj-PB
    stj-PC
    stj-PD
    straight-jacket

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13805794..13819571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137058.4 → NP_610902.1  straightjacket, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0H4
      Related
      FBpp0086757
      Conserved Domains (3) summary
      cd01463
      Location:253 → 439
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:524 → 601
      Cache_1; Cache domain
      pfam08399
      Location:107 → 241
      VWA_N; VWA N-terminal

    2. NM_001259375.2 → NP_001246304.1  straightjacket, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7P4
      Conserved Domains (3) summary
      cd01463
      Location:253 → 439
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:524 → 620
      Cache_1; Cache domain
      pfam08399
      Location:107 → 241
      VWA_N; VWA N-terminal

    3. NM_001259374.2 → NP_001246303.1  straightjacket, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K866
      Conserved Domains (3) summary
      cd01463
      Location:253 → 439
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:524 → 619
      Cache_1; Cache domain
      pfam08399
      Location:107 → 241
      VWA_N; VWA N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7P4 A0A0B4K7P4
    A0A0B4K866 A0A0B4K866
    Q7K0H4 Q7K0H4
    Q95R75 Q95R75

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