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    mol moladietz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    molprovided by FlyBase
    Official Full Name
    moladietzprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086711
    Locus tag
    Dmel_CG4482
    See related
    AllianceGenome:FB:FBgn0086711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    35Bb; B1; BG:DS01219.1; br3; CG15268; CG4482; Dmel\CG4482; l(2)35Bb; l(2)br23; l(2)br3; l(2)SH1330; l(2)SH2 1330; l35Bb; Mol; nip; NIP
    Summary
    Involved in long-term memory; protein localization; and response to oxidative stress. Located in basal part of cell and plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to several human genes including DUOXA1 (dual oxidase maturation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See mol in Genome Data Viewer
    Location:
    35B7-35B8; 2-50 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14975747..14997559, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14975747..14997559, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene sidestep II Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45331 Neighboring gene Dynactin 5, p25 subunit Neighboring gene Ankrd49 Neighboring gene Negative Cofactor 2beta Neighboring gene tRNA-histidine guanylyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response. Xie X, et al. Int J Biol Sci, 2010 May 11. PMID 20567495, Free PMC Article
    2. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. McNabb S, et al. Genetics, 1996 Jun. PMID 8725237, Free PMC Article
    3. Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release. Razzell W, et al. Curr Biol, 2013 Mar 4. PMID 23394834, Free PMC Article
    4. Drosophila hemocytes recognize lymph gland tumors of mxc mutants and activate the innate immune pathway in a reactive oxygen species-dependent manner. Kinoshita S, et al. Biol Open, 2022 Nov 1. PMID 36226812, Free PMC Article
    5. Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. Fossett NG, et al. Mutat Res, 1990 Jul. PMID 2114535

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that high expression of the gene moladietz (mol), which encodes the Duox-maturation factor NIP, is required during regeneration to produce reactive oxygen species (ROS), which in turn sustain JNK signaling during regeneration. We also show that JNK signaling upregulates mol expression, thereby activating a positive feedback signal that ensures the prolonged JNK activation required for regenerative growth.
      Title: The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling.
    2. direct protein-protein interaction between numb-interacting protein (NIP) and Numb is necessary and sufficient for the recruitment of Numb to the plasma membrane
      Title: A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    moladietz
    Names
    CG4482-PA
    CG4482-PC
    CG4482-PD
    CG4482-PF
    CG4482-PG
    lethal (2) 35Bb
    lethal (2) SH1330
    lethal 23 in the black-reduced region
    lethal 3 in the black-reduced region
    lethal group B1
    mol-PA
    mol-PC
    mol-PD
    mol-PF
    mol-PG
    numb-interacting protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14975747..14997559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042899.2 → NP_001036364.2  moladietz, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036364.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ0, Q9VJQ7
      Conserved Domains (1) summary
      pfam10204
      Location:18 → 289
      DuoxA; Dual oxidase maturation factor

    2. NM_165094.3 → NP_723890.2  moladietz, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723890.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT87
      Conserved Domains (1) summary
      pfam10204
      Location:1 → 145
      DuoxA; Dual oxidase maturation factor

    3. NM_135889.4 → NP_609733.1  moladietz, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ0, Q9VJQ7
      Related
      FBpp0080238
      Conserved Domains (1) summary
      pfam10204
      Location:18 → 289
      DuoxA; Dual oxidase maturation factor

    4. NM_001042898.2 → NP_001036363.1  moladietz, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ0, Q9VJQ7
      Conserved Domains (1) summary
      pfam10204
      Location:18 → 289
      DuoxA; Dual oxidase maturation factor

    5. NM_001042897.2 → NP_001036362.1  moladietz, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ0, Q9VJQ7
      Conserved Domains (1) summary
      pfam10204
      Location:18 → 289
      DuoxA; Dual oxidase maturation factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KT87 Q7KT87
    Q9VJQ7 Q9VJQ7

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