Khc Kinesin heavy chain [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Khcprovided by FlyBase
Official Full Name: Kinesin heavy chainprovided by FlyBase
Primary source: FLYBASE:FBgn0001308
Locus tag: Dmel_CG7765
See related: AllianceGenome:FB:FBgn0001308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2R6; CG7765; DK; DKH; Dm KHC; Dmel\CG7765; DmK; DmKHC; Dmkin; khc; KHC; KIF 5A; Kif5; KIF5; KIF5B; kin; Kin; KIN; Kin-1; kinesin; Kinesin; kinesin-1; Kinesin-1; l(2)k13219; l(2)k13314; l(2)W12; l(2R)W12; pgs
Summary: Enables microtubule binding activity; microtubule motor activity; and tropomyosin binding activity. Involved in several processes, including cytoskeleton organization; neuron differentiation; and oocyte axis specification. Located in actin cap; axon cytoplasm; and microtubule plus-end. Part of kinesin complex. Is expressed in several structures, including adult heart; germline cell; glial cell; head; and photoreceptor neurons. Used to study hereditary spastic paraplegia; motor neuron disease; neurodegenerative disease; and spinal muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 25; autoimmune disease (multiple); complex cortical dysplasia with other brain malformations 2; hereditary spastic paraplegia 10; and prostate cancer. Orthologous to several human genes including KIF5B (kinesin family member 5B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53A3-53A4; 2-79 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16266960..16271971, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12154465..12159476, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte.
Title: Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte.
Pericentrin interacts with Kinesin-1 to drive centriole motility.
Title: Pericentrin interacts with Kinesin-1 to drive centriole motility.
Kinesin-1 captures RNA cargo in its adaptable coils.
Title: Kinesin-1 captures RNA cargo in its adaptable coils.
A stop or go switch: glycogen synthase kinase 3beta phosphorylation of the kinesin 1 motor domain at Ser314 halts motility without detaching from microtubules.
Title: A stop or go switch: glycogen synthase kinase 3β phosphorylation of the kinesin 1 motor domain at Ser314 halts motility without detaching from microtubules.
Competition between kinesin-1 and myosin-V defines Drosophila posterior determination.
Title: Competition between kinesin-1 and myosin-V defines Drosophila posterior determination.
The temperature dependence of kinesin motor-protein mechanochemistry.
Title: The temperature dependence of kinesin motor-protein mechanochemistry.
The results verify quantitatively the qualitative model of the microtubule polarity sorting and suggest that dynein-powered elongation is effective only when the processes are longer than a threshold length, which explains why kinesin-1 alone, but not dynein, is sufficient for the process growth.
Title: Microtubule Dynamics, Kinesin-1 Sliding, and Dynein Action Drive Growth of Cell Processes.
enetic interaction tests show that a balance of kinesin-1 inhibition and dynein activity is necessary to localize Golgi outposts to dendrites and keep them from entering axons. Our data indicate that kinesin-1 activity is precisely regulated by autoinhibition to achieve the selective localization of dendritic cargo
Title: Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts.
The results demonstrate that microtubule sliding by kinesin-1 is an essential biological phenomenon required for neuronal morphogenesis and normal nervous system development.
Title: Role of kinesin-1-based microtubule sliding in Drosophila nervous system development.
Kinesin-1 slides free cytoplasmic microtubules against cortically immobilized microtubules, generating forces that contribute to cytoplasmic streaming and are essential for the refinement of posterior determinants.
Title: Microtubule-microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in Drosophila oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3298 (e-PCR)
- UniSTS:515675

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	NAS Non-traceable Author Statement more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables tropomyosin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule sliding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion distribution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	TAS Traceable Author Statement more info	PubMed
involved_in pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm oskar mRNA localization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in stress granule disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transport along microtubule	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin cap	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin heavy chain

Names: CG7765-PA; KHC; Khc-PA; Kin-1 heavy chain; Kinesin14; conventional kinesin; heavy chain of kinesin; kinesin; kinesin -1; kinesin 1; kinesin I; kinesin alpha subunit; kinesin alpha-chain; kinesin heavy chain I; kinesin-1; kinesin-1 heavy chain; partagas

NP_476590.1

EC 5.6.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16266960..16271971 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057242.5 → NP_476590.1 kinesin heavy chain [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476590.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17210, Q9V7L9

Related

FBpp0086328

Conserved Domains (3) summary

smart00129
Location:12 → 340

KISc; Kinesin motor, catalytic domain. ATPase

cd01369
Location:10 → 333

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

pfam01442
Location:595 → 744

Apolipoprotein; Apolipoprotein A1/A4/E domain