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    Pacs1 phosphofurin acidic cluster sorting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171444, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pacs1provided by RGD
    Official Full Name
    phosphofurin acidic cluster sorting protein 1provided by RGD
    Primary source
    RGD:620579
    See related
    EnsemblRapid:ENSRNOG00000020350 AllianceGenome:RGD:620579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pacs-1
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in lymphocyte homeostasis and protein localization to plasma membrane. Predicted to act upstream of or within protein localization to Golgi apparatus. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome. Orthologous to human PACS1 (phosphofurin acidic cluster sorting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 61.4), Testes (RPKM 61.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pacs1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211866872..211998828, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202437503..202569473, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220515117..220645611, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555354 Neighboring gene uncharacterized LOC120099979 Neighboring gene RAB1B, member RAS oncogene family Neighboring gene kinesin light chain 2 Neighboring gene uncharacterized LOC120099980 Neighboring gene F11 receptor, pseudogene 1 Neighboring gene splicing factor 3b, subunit 2 Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene cation channel, sperm associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in lymphocyte homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in COPI-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in COPI-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphofurin acidic cluster sorting protein 1
    Names
    cytosolic sorting protein PACS-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134406.1NP_599233.1  phosphofurin acidic cluster sorting protein 1

      See identical proteins and their annotated locations for NP_599233.1

      Status: PROVISIONAL

      Source sequence(s)
      AF076183
      UniProtKB/Swiss-Prot
      O88588, O88589
      UniProtKB/TrEMBL
      A6HZ35, F1LPG3
      Related
      ENSRNOP00000027632.5, ENSRNOT00000027632.7
      Conserved Domains (1) summary
      pfam10254
      Location:546958
      Pacs-1; PACS-1 cytosolic sorting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211866872..211998828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)