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    Gk glycerol kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gkprovided by RGD
    Official Full Name
    glycerol kinaseprovided by RGD
    Primary source
    RGD:70893
    See related
    EnsemblRapid:ENSRNOG00000034116 AllianceGenome:RGD:70893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gyk; ASTP
    Summary
    Enables histone binding activity. Involved in response to ethanol; response to norepinephrine; and response to xenobiotic stimulus. Predicted to be located in cytosol and nucleus. Predicted to be active in mitochondrion. Used to study familial hypercholesterolemia. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to several human genes including GK (glycerol kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1065.8), Kidney (RPKM 718.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (54106708..54189940, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (50162089..50238707, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (54227291..54303897, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene xanthine dehydrogenase, pseudogene 1 Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene uncharacterized LOC134484150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycerol kinase and dihydroxyacetone kinase in rat brain. Jenkins BT, et al. J Neurochem, 1976 Feb. PMID 3631
    2. Properties of an adenosine triphosphate-stimulated factor that enhances the nuclear binding of activated glucocorticoid-receptor complex: binding to histone-agarose. Okamoto K, et al. Endocrinology, 1989 Feb. PMID 2912694
    3. Human and rat adrenal glycerol kinase: subcellular distribution and bisubstrate kinetics. Seltzer WK, et al. Mol Cell Biochem, 1984 Apr. PMID 6330523
    4. Molecular cloning of rat liver glucocorticoid-receptor translocation promoter. Okamoto K, et al. Biochem Biophys Res Commun, 1993 Jun 30. PMID 8323560
    5. Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells. Sriram G, et al. Metab Eng, 2010 Jul. PMID 20399282, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. To further elucidate the contributions of the enzymatic (phosphorylation) and alternative (ASTP) functions of GK in adipogenesis, we performed experiments on mammalian GK and E. coli GK. We determined that the ASTP function of GK (which is absent in E. coli GK) plays a greater role than the enzymatic activity in these processes.
      Title: The ATP-stimulated translocation promoter (ASTP) activity of glycerol kinase plays central role in adipogenesis.
    2. This systems biology approach further emphasizes glucose kinase's essential role in central and lipid metabolism and experimentally verifies lucose kinase's alternative function of affecting glucocorticoid receptor transcription factor activity.
      Title: Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to norepinephrine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycerol kinase
    Names
    ATP-stimulated glucocorticoid-receptor translocation promoter
    ATP-stimulated glucocorticoid-receptor translocaton promoter
    ATP:glycerol 3-phosphotransferase
    glycerokinase
    NP_077357.2
    XP_006257049.1
    XP_006257050.1
    XP_008771496.1
    XP_008771497.1
    XP_008771498.1
    XP_008771500.1
    XP_038956015.1
    XP_063136391.1
    XP_063136392.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024381.2 → NP_077357.2  glycerol kinase

      Status: VALIDATED

      Source sequence(s)
      CO557097, CO564445, D16102, JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IPW2
      Related
      ENSRNOP00000102933.1, ENSRNOT00000158613.1
      Conserved Domains (2) summary
      cd07792
      Location:11 → 513
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 513
      glycerol_kin; glycerol kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      54106708..54189940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773276.4 → XP_008771498.1  glycerol kinase isoform X4

      UniProtKB/TrEMBL
      A6IPW2
      Conserved Domains (2) summary
      cd07792
      Location:11 → 547
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 547
      glycerol_kin; glycerol kinase

    2. XM_006256987.5 → XP_006257049.1  glycerol kinase isoform X5

      UniProtKB/Swiss-Prot
      A0A0G2K785, Q63060
      UniProtKB/TrEMBL
      A6IPW2
      Related
      ENSRNOP00000074103.1, ENSRNOT00000087547.3
      Conserved Domains (2) summary
      cd07792
      Location:11 → 519
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 519
      glycerol_kin; glycerol kinase

    3. XM_006256988.5 → XP_006257050.1  glycerol kinase isoform X7

      UniProtKB/TrEMBL
      A6IPW2
      Related
      ENSRNOP00000108996.1, ENSRNOT00000153646.1
      Conserved Domains (2) summary
      cd07792
      Location:11 → 513
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 513
      glycerol_kin; glycerol kinase

    4. XM_063280322.1 → XP_063136392.1  glycerol kinase isoform X9

      UniProtKB/TrEMBL
      A6IPW2, D3ZCI0, F1LSY6
      Related
      ENSRNOP00000048795.5, ENSRNOT00000051249.7

    5. XM_063280321.1 → XP_063136391.1  glycerol kinase isoform X8

      UniProtKB/TrEMBL
      A0A8J8YI12, A6IPW2
      Related
      ENSRNOP00000059825.2, ENSRNOT00000064340.5

    6. XM_008773275.4 → XP_008771497.1  glycerol kinase isoform X2

      UniProtKB/TrEMBL
      A6IPW2
      Conserved Domains (2) summary
      cd07792
      Location:11 → 541
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 541
      glycerol_kin; glycerol kinase

    7. XM_008773278.4 → XP_008771500.1  glycerol kinase isoform X6

      UniProtKB/TrEMBL
      A6IPW2
      Conserved Domains (2) summary
      cd07792
      Location:11 → 547
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 547
      glycerol_kin; glycerol kinase

    8. XM_008773274.4 → XP_008771496.1  glycerol kinase isoform X1

      UniProtKB/TrEMBL
      A6IPW2
      Conserved Domains (2) summary
      cd07792
      Location:11 → 547
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11 → 547
      glycerol_kin; glycerol kinase

    9. XM_039100087.2 → XP_038956015.1  glycerol kinase isoform X3

      UniProtKB/TrEMBL
      A6IPW2
      Related
      ENSRNOP00000103355.1, ENSRNOT00000137012.1
      Conserved Domains (1) summary
      cd07792
      Location:11 → 547
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63060.2 GenPept UniProtKB/Swiss-Prot:Q63060

    Gene LinkOut

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