Amotl1 angiomotin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amotl1provided by RGD
Official Full Name: angiomotin-like 1provided by RGD
Primary source: RGD:1305268
See related: EnsemblRapid:ENSRNOG00000008990 AllianceGenome:RGD:1305268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to act upstream of or within establishment of cell polarity involved in ameboidal cell migration; establishment of epithelial cell polarity; and positive regulation of blood vessel endothelial cell migration. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Predicted to be part of COP9 signalosome. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 685.2), Lung (RPKM 153.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (19630139..19749027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11348651..11467564, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (13037265..13157701, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity involved in ameboidal cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: angiomotin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429440.1 → NP_001416369.1 angiomotin-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5Y7F3
NM_001429441.1 → NP_001416370.1 angiomotin-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6A227
NM_001429442.1 → NP_001416371.1 angiomotin-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

19630139..19749027 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082231.2 → XP_038938159.1 angiomotin-like protein 1 isoform X2

UniProtKB/TrEMBL

F1LZQ6

Conserved Domains (2) summary

COG1196
Location:520 → 743

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:657 → 863

Angiomotin_C; Angiomotin C terminal
XM_039082232.2 → XP_038938160.1 angiomotin-like protein 1 isoform X3

Related

ENSRNOP00000077333.2, ENSRNOT00000097452.2

Conserved Domains (2) summary

COG1196
Location:513 → 736

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:650 → 856

Angiomotin_C; Angiomotin C terminal
XM_039082230.2 → XP_038938158.1 angiomotin-like protein 1 isoform X1

UniProtKB/TrEMBL

F1LZQ6

Conserved Domains (2) summary

COG1196
Location:521 → 744

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:658 → 864

Angiomotin_C; Angiomotin C terminal
XM_039082234.2 → XP_038938162.1 angiomotin-like protein 1 isoform X6

UniProtKB/TrEMBL

F1LZQ6

Conserved Domains (2) summary

COG1196
Location:390 → 613

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:527 → 733

Angiomotin_C; Angiomotin C terminal
XM_039082233.2 → XP_038938161.1 angiomotin-like protein 1 isoform X4

Related

ENSRNOP00000084828.2, ENSRNOT00000103850.2

Conserved Domains (2) summary

COG1196
Location:476 → 699

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:613 → 819

Angiomotin_C; Angiomotin C terminal
XM_063266287.1 → XP_063122357.1 angiomotin-like protein 1 isoform X5

Related

ENSRNOP00000058333.5, ENSRNOT00000061616.6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108126.1: Suppressed sequence

Description

NM_001108126.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: Amotl1 (GeneID:75723).