Nme6 NME/NM23 nucleoside diphosphate kinase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nme6provided by RGD
Official Full Name: NME/NM23 nucleoside diphosphate kinase 6provided by RGD
Primary source: RGD:61896
See related: EnsemblRapid:ENSRNOG00000020721 AllianceGenome:RGD:61896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nm23-R6
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 47.8), Heart (RPKM 44.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118708092..118717756)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109832085..109839301)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117920912..117928148)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoside diphosphate kinase 6

Names: NDK 6; NDP kinase 6; expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase); expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase); non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase type 6

NP_001178813.1

EC 2.7.4.6

XP_006243909.1

EC 2.7.4.6

XP_006243910.1

EC 2.7.4.6

XP_006243911.1

EC 2.7.4.6

XP_006243912.1

EC 2.7.4.6

XP_006243913.1

EC 2.7.4.6

XP_017451369.1

EC 2.7.4.6

XP_038937966.1

EC 2.7.4.6

XP_038937967.1

EC 2.7.4.6

XP_038937969.1

EC 2.7.4.6

XP_063122119.1

EC 2.7.4.6

XP_063122120.1

EC 2.7.4.6

XP_063122121.1

EC 2.7.4.6

XP_063122122.1

EC 2.7.4.6

XP_063122123.1

EC 2.7.4.6

XP_063122125.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191884.2 → NP_001178813.1 nucleoside diphosphate kinase 6

See identical proteins and their annotated locations for NP_001178813.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C2, R9PXW5

Conserved Domains (2) summary

smart00562
Location:12 → 149

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:12 → 146

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
NM_001431584.1 → NP_001418513.1 nucleoside diphosphate kinase 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C2, R9PXW5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118708092..118717756

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243849.3 → XP_006243911.1 nucleoside diphosphate kinase 6 isoform X1

See identical proteins and their annotated locations for XP_006243911.1

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C2, R9PXW5

Conserved Domains (2) summary

smart00562
Location:12 → 149

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:12 → 146

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
XM_006243848.5 → XP_006243910.1 nucleoside diphosphate kinase 6 isoform X1

Conserved Domains (2) summary

smart00562
Location:12 → 149

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:12 → 146

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
XM_063266051.1 → XP_063122121.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3
XM_006243847.5 → XP_006243909.1 nucleoside diphosphate kinase 6 isoform X1

See identical proteins and their annotated locations for XP_006243909.1

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C2, R9PXW5

Conserved Domains (2) summary

smart00562
Location:12 → 149

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:12 → 146

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
XM_063266050.1 → XP_063122120.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3
XM_039082039.2 → XP_038937967.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3

Conserved Domains (1) summary

cl00335
Location:1 → 101

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
XM_063266049.1 → XP_063122119.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3
XM_039082038.2 → XP_038937966.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3

Conserved Domains (1) summary

cl00335
Location:1 → 101

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
XM_006243850.5 → XP_006243912.1 nucleoside diphosphate kinase 6 isoform X1

See identical proteins and their annotated locations for XP_006243912.1

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C2, R9PXW5

Conserved Domains (2) summary

smart00562
Location:12 → 149

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:12 → 146

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
XM_063266055.1 → XP_063122125.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3
XM_039082041.2 → XP_038937969.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3

Conserved Domains (1) summary

cl00335
Location:1 → 101

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
XM_006243851.4 → XP_006243913.1 nucleoside diphosphate kinase 6 isoform X1

See identical proteins and their annotated locations for XP_006243913.1

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C2, R9PXW5

Related

ENSRNOP00000028125.6, ENSRNOT00000028125.9

Conserved Domains (2) summary

smart00562
Location:12 → 149

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04414
Location:12 → 146

NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
XM_063266053.1 → XP_063122123.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3
XM_063266052.1 → XP_063122122.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3
XM_017595880.3 → XP_017451369.1 nucleoside diphosphate kinase 6 isoform X2

UniProtKB/Swiss-Prot

O88426

UniProtKB/TrEMBL

A6I3C3

Conserved Domains (1) summary

cl00335
Location:1 → 101

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...