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    Tsfm Ts translation elongation factor, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679068, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tsfmprovided by RGD
    Official Full Name
    Ts translation elongation factor, mitochondrialprovided by RGD
    Primary source
    RGD:1593058
    See related
    EnsemblRapid:ENSRNOG00000048843 AllianceGenome:RGD:1593058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    2A3-2; EF-Ts; EF-TsMt
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Predicted to be located in mitochondrion and nucleoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 131.4), Adrenal (RPKM 113.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tsfm in Genome Data Viewer
    Location:
    7q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64714330..64750106, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62828997..62864784, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70311948..70319389, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351472 Neighboring gene CTD small phosphatase 2 Neighboring gene advillin Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy. Emperador S, et al. Eur J Hum Genet, 2016 Jan. PMID 27677415, Free PMC Article
    2. Identification and cloning of a new gene (2A3-2), homologous to human translational elongation factor, upregulated in a proliferating rat smooth muscle cell line and in carotid hyperplasia. Zibara K, et al. Arterioscler Thromb Vasc Biol, 1999 Jul. PMID 10397682
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor Ts, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276476.1 → NP_001263405.1  elongation factor Ts, mitochondrial precursor

      Status: PROVISIONAL

      Source sequence(s)
      FQ220263
      UniProtKB/Swiss-Prot
      Q9QYU2
      Related
      ENSRNOP00000086749.1, ENSRNOT00000099205.2
      Conserved Domains (3) summary
      PRK09377
      Location:47 → 317
      tsf; elongation factor Ts; Provisional
      cd14275
      Location:47 → 83
      UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes
      pfam00889
      Location:115 → 316
      EF_TS; Elongation factor TS

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64714330..64750106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079876.2 → XP_038935804.1  elongation factor Ts, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I6GEC9
      Conserved Domains (1) summary
      PRK09377
      Location:36 → 306
      tsf; elongation factor Ts; Provisional

    2. XM_039079874.2 → XP_038935802.1  elongation factor Ts, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9QYU2
      Conserved Domains (1) summary
      PRK09377
      Location:47 → 317
      tsf; elongation factor Ts; Provisional

    3. XM_039079875.2 → XP_038935803.1  elongation factor Ts, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q9QYU2
      Related
      ENSRNOP00000107892.1, ENSRNOT00000136728.1
      Conserved Domains (1) summary
      PRK09377
      Location:47 → 316
      tsf; elongation factor Ts; Provisional

    4. XM_039079877.2 → XP_038935805.1  elongation factor Ts, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      Q9QYU2
      Related
      ENSRNOP00000064332.4, ENSRNOT00000071543.4
      Conserved Domains (1) summary
      PRK09377
      Location:47 → 318
      tsf; elongation factor Ts; Provisional

    RNA

    1. XR_005486720.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYU2.1 GenPept UniProtKB/Swiss-Prot:Q9QYU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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