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    Adcy8 adenylate cyclase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29241, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adcy8provided by RGD
    Official Full Name
    adenylate cyclase 8provided by RGD
    Primary source
    RGD:2036
    See related
    EnsemblRapid:ENSRNOG00000004890 AllianceGenome:RGD:2036
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ac8
    Summary
    Enables several functions, including calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of protein kinase A activity; and cAMP biosynthetic process. Located in several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 50.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adcy8 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (98306434..98555687, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (96417310..96665911, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (105353883..105593372, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479920 Neighboring gene CYFIP related Rac1 interactor B Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Neighboring gene uncharacterized LOC134479921 Neighboring gene proteasome 20S subunit beta 3 like 3 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium- and calmodulin-responsive adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium- and calmodulin-responsive adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase 2A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of protein kinase A activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP/PKA signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to forskolin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucagon stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucagon stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to morphine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to morphine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuroinflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenylate cyclase type 8
    Names
    ATP pyrophosphate-lyase 8
    adenylate cyclase 8 (brain)
    adenylate cyclase type VIII
    adenylyl cyclase 8
    ca(2+)/calmodulin-activated adenylyl cyclase
    type VIII adenylyl cyclase
    NP_058838.1
    XP_006241765.1
    XP_006241766.1
    XP_038934491.1
    XP_038934492.1
    XP_038934493.1
    XP_038934495.1
    XP_063119182.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017142.1NP_058838.1  adenylate cyclase type 8

      See identical proteins and their annotated locations for NP_058838.1

      Status: PROVISIONAL

      Source sequence(s)
      L26986
      UniProtKB/Swiss-Prot
      P40146
      UniProtKB/TrEMBL
      A6HRQ4, G3V6N0
      Related
      ENSRNOP00000006789.4, ENSRNOT00000006789.8
      Conserved Domains (4) summary
      smart00044
      Location:363561
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9701169
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:614708
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:158397
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      98306434..98555687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078567.2XP_038934495.1  adenylate cyclase type 8 isoform X7

      UniProtKB/TrEMBL
      A0A2Z4LIN0
      Conserved Domains (2) summary
      pfam00211
      Location:736935
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:179259
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    2. XM_039078565.2XP_038934493.1  adenylate cyclase type 8 isoform X6

      UniProtKB/TrEMBL
      A0A2Z4LIN4
      Conserved Domains (2) summary
      pfam00211
      Location:766965
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:179259
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    3. XM_039078564.2XP_038934492.1  adenylate cyclase type 8 isoform X5

      UniProtKB/TrEMBL
      A0A2Z4LIN1
      Conserved Domains (3) summary
      pfam00211
      Location:8021001
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:179259
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:476570
      DUF1053; Domain of Unknown Function (DUF1053)
    4. XM_063263112.1XP_063119182.1  adenylate cyclase type 8 isoform X3

      UniProtKB/TrEMBL
      A6HRQ4, G3V6N0
    5. XM_006241704.5XP_006241766.1  adenylate cyclase type 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3U3, A6HRQ4, G3V6N0
      Related
      ENSRNOP00000085627.1, ENSRNOT00000096414.2
      Conserved Domains (4) summary
      smart00044
      Location:363561
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9041103
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:614636
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:158397
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    6. XM_039078563.2XP_038934491.1  adenylate cyclase type 8 isoform X4

      UniProtKB/TrEMBL
      A0A2Z4LIM7
      Conserved Domains (3) summary
      pfam00211
      Location:8321031
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:179259
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:476570
      DUF1053; Domain of Unknown Function (DUF1053)
    7. XM_006241703.5XP_006241765.1  adenylate cyclase type 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GDK4, A6HRQ4, G3V6N0
      Related
      ENSRNOP00000086009.1, ENSRNOT00000098906.2
      Conserved Domains (4) summary
      smart00044
      Location:363561
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9401139
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:614708
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:158397
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region