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    Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311821, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Agpat2provided by RGD
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 2provided by RGD
    Primary source
    RGD:1309229
    See related
    EnsemblRapid:ENSRNOG00000019466 AllianceGenome:RGD:1309229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in epidermis development and response to xenobiotic stimulus. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 894.1), Thymus (RPKM 467.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agpat2 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29814924..29826569, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9416837..9428567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (4044741..4055384, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 198 Neighboring gene EGF-like-domain, multiple 7 Neighboring gene microRNA 126a Neighboring gene microRNA 126b Neighboring gene divergent protein kinase domain 1B Neighboring gene uncharacterized LOC100911266 Neighboring gene small nucleolar RNA SNORA43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. McHugh PC, et al. J Psychopharmacol, 2010 Aug. PMID 19346281
    2. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cortés VA, et al. Cell Metab, 2009 Feb. PMID 19187773, Free PMC Article
    3. Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy. Haque W, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629135
    4. Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. Eberhardt C, et al. J Biol Chem, 1997 Aug 8. PMID 9242711
    5. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Agarwal AK, et al. Nat Genet, 2002 May. PMID 11967537

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermis development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase beta
    Names
    1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
    NP_001101291.1
    XP_038961130.1
    XP_038961131.1
    XP_038961133.1
    XP_038961134.1
    XP_038961135.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107821.3 → NP_001101291.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta

      See identical proteins and their annotated locations for NP_001101291.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JTG5
      Conserved Domains (1) summary
      cd07989
      Location:67 → 240
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29814924..29826569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105202.2 → XP_038961130.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1

      UniProtKB/TrEMBL
      D4AC45
      Related
      ENSRNOP00000026408.5, ENSRNOT00000026408.9
      Conserved Domains (1) summary
      cd07989
      Location:54 → 227
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    2. XM_039105207.2 → XP_038961135.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

      Conserved Domains (1) summary
      cd07989
      Location:4 → 137
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    3. XM_039105203.2 → XP_038961131.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

      Conserved Domains (1) summary
      cd07989
      Location:4 → 137
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    4. XM_039105205.2 → XP_038961133.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

      Conserved Domains (1) summary
      cd07989
      Location:4 → 137
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    5. XM_039105206.2 → XP_038961134.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

      Conserved Domains (1) summary
      cd07989
      Location:4 → 137
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    Nucleotide Protein Strain
    Heading Accession and Version

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