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    Slc26a8 solute carrier family 26 member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc26a8provided by RGD
    Official Full Name
    solute carrier family 26 member 8provided by RGD
    Primary source
    RGD:1308898
    See related
    EnsemblRapid:ENSRNOG00000000512 AllianceGenome:RGD:1308898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chloride transmembrane transporter activity and organic anion transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport; oxalate transport; and sulfate transmembrane transport. Predicted to be located in sperm annulus. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 3. Orthologous to human SLC26A8 (solute carrier family 26 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 102.4), Liver (RPKM 30.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc26a8 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6687207..6751184, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6686206..6749478, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5870714..5933151, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene SRSF protein kinase 1 Neighboring gene uncharacterized LOC120098971 Neighboring gene mitogen activated protein kinase 14 Neighboring gene uncharacterized LOC134483779

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension. Mocellin R, et al. Eur J Cardiol, 1975 Oct. PMID 1183472
    2. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. Toure A, et al. J Biol Chem, 2001 Jun 8. PMID 11278976
    3. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. Lohi H, et al. J Biol Chem, 2002 Apr 19. PMID 11834742
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxalate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate:chloride antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxalate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis anion transporter 1
    Names
    solute carrier family 26 (anion exchanger), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107614.4 → NP_001101084.2  testis anion transporter 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0U1RS37, F7F9X9
      Related
      ENSRNOP00000056031.4, ENSRNOT00000059264.6
      Conserved Domains (2) summary
      cd07042
      Location:697 → 772
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:76 → 582
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6687207..6751184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279130.1 → XP_063135200.1  testis anion transporter 1 isoform X1

      UniProtKB/TrEMBL
      F7F9X9

    2. XM_063279137.1 → XP_063135207.1  testis anion transporter 1 isoform X11

      UniProtKB/TrEMBL
      F7F9X9
      Related
      ENSRNOP00000111887.1, ENSRNOT00000143144.1

    3. XM_063279134.1 → XP_063135204.1  testis anion transporter 1 isoform X5

      UniProtKB/TrEMBL
      F7F9X9

    4. XM_063279139.1 → XP_063135209.1  testis anion transporter 1 isoform X15

      UniProtKB/TrEMBL
      F7F9X9

    5. XM_063279135.1 → XP_063135205.1  testis anion transporter 1 isoform X8

      UniProtKB/TrEMBL
      F7F9X9

    6. XM_063279136.1 → XP_063135206.1  testis anion transporter 1 isoform X10

      UniProtKB/TrEMBL
      F7F9X9

    7. XM_063279133.1 → XP_063135203.1  testis anion transporter 1 isoform X4

      UniProtKB/TrEMBL
      F7F9X9
      Related
      ENSRNOP00000111378.1, ENSRNOT00000141151.1

    8. XM_063279132.1 → XP_063135202.1  testis anion transporter 1 isoform X3

      UniProtKB/TrEMBL
      F7F9X9

    9. XM_063279129.1 → XP_063135199.1  testis anion transporter 1 isoform X1

      UniProtKB/TrEMBL
      F7F9X9

    10. XM_063279142.1 → XP_063135212.1  testis anion transporter 1 isoform X20

    11. XM_063279138.1 → XP_063135208.1  testis anion transporter 1 isoform X14

      UniProtKB/TrEMBL
      F7F9X9

    12. XM_039098696.2 → XP_038954624.1  testis anion transporter 1 isoform X7

      UniProtKB/TrEMBL
      F7F9X9
      Conserved Domains (2) summary
      cd07042
      Location:691 → 766
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:90 → 485
      Sulfate_transp; Sulfate permease family

    13. XM_039098699.2 → XP_038954627.1  testis anion transporter 1 isoform X16

      UniProtKB/TrEMBL
      F7F9X9
      Conserved Domains (2) summary
      cd07042
      Location:645 → 720
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:90 → 320
      Sulfate_transp; Sulfate permease family

    14. XM_039098697.2 → XP_038954625.1  testis anion transporter 1 isoform X9

      UniProtKB/TrEMBL
      F7F9X9
      Conserved Domains (2) summary
      cd07042
      Location:677 → 752
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:90 → 471
      Sulfate_transp; Sulfate permease family

    15. XM_008772780.4 → XP_008771002.1  testis anion transporter 1 isoform X12

      See identical proteins and their annotated locations for XP_008771002.1

      UniProtKB/TrEMBL
      F7F9X9
      Related
      ENSRNOP00000100273.1, ENSRNOT00000156098.1
      Conserved Domains (2) summary
      cd07042
      Location:665 → 740
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:90 → 455
      Sulfate_transp; Sulfate permease family

    16. XM_039098695.2 → XP_038954623.1  testis anion transporter 1 isoform X6

      UniProtKB/TrEMBL
      F7F9X9
      Conserved Domains (2) summary
      cd07042
      Location:698 → 773
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:90 → 488
      Sulfate_transp; Sulfate permease family

    17. XM_063279131.1 → XP_063135201.1  testis anion transporter 1 isoform X2

      UniProtKB/TrEMBL
      F7F9X9
      Related
      ENSRNOP00000075921.2, ENSRNOT00000092383.3

    18. XM_063279140.1 → XP_063135210.1  testis anion transporter 1 isoform X17

      UniProtKB/TrEMBL
      F7F9X9

    19. XM_039098698.2 → XP_038954626.1  testis anion transporter 1 isoform X13

      UniProtKB/TrEMBL
      F7F9X9
      Conserved Domains (2) summary
      cd07042
      Location:660 → 735
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:20 → 454
      Sulfate_transp; Sulfate permease family

    20. XM_063279141.1 → XP_063135211.1  testis anion transporter 1 isoform X19

      UniProtKB/TrEMBL
      F7F9X9

    21. XM_039098700.2 → XP_038954628.1  testis anion transporter 1 isoform X18

      UniProtKB/TrEMBL
      F7F9X9
      Conserved Domains (2) summary
      cd07042
      Location:587 → 662
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:50 → 381
      Sulfate_transp; Sulfate permease family

    22. XM_063279145.1 → XP_063135215.1  testis anion transporter 1 isoform X22

    23. XM_063279143.1 → XP_063135213.1  testis anion transporter 1 isoform X21

    24. XM_063279144.1 → XP_063135214.1  testis anion transporter 1 isoform X22

    RNA

    1. XR_010060687.1 RNA Sequence

    2. XR_010060692.1 RNA Sequence

    3. XR_010060690.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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