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    Ces4a carboxylesterase 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ces4aprovided by RGD
    Official Full Name
    carboxylesterase 4Aprovided by RGD
    Primary source
    RGD:1307418
    See related
    EnsemblRapid:ENSRNOG00000014257 AllianceGenome:RGD:1307418
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ces8; RGD1307418
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Orthologous to human CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 25.1), Testes (RPKM 18.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ces4a in Genome Data Viewer
    Location:
    19q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (49921643..49942838)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33011731..33030119)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37090018..37111448)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2H Neighboring gene carboxylesterase 3a Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 4A
    Names
    carboxylesterase 8 (putative)
    NP_001099646.1
    XP_038953520.1
    XP_038953521.1
    XP_038953522.1
    XP_038953523.1
    XP_038953524.1
    XP_038953525.1
    XP_038953526.1
    XP_038953527.1
    XP_063133971.1
    XP_063133972.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106176.1 → NP_001099646.1  carboxylesterase 4A precursor

      See identical proteins and their annotated locations for NP_001099646.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IYL9, D4AE76
      Related
      ENSRNOP00000019169.2, ENSRNOT00000019169.5
      Conserved Domains (1) summary
      pfam00135
      Location:33 → 554
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      49921643..49942838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277901.1 → XP_063133971.1  carboxylesterase 4A isoform X1

    2. XM_039097599.2 → XP_038953527.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    3. XM_039097596.2 → XP_038953524.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    4. XM_063277902.1 → XP_063133972.1  carboxylesterase 4A isoform X3

    5. XM_039097593.2 → XP_038953521.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    6. XM_039097598.2 → XP_038953526.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    7. XM_039097594.2 → XP_038953522.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    8. XM_039097597.2 → XP_038953525.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    9. XM_039097595.2 → XP_038953523.1  carboxylesterase 4A isoform X4

      Conserved Domains (1) summary
      pfam00135
      Location:15 → 449
      COesterase; Carboxylesterase family

    10. XM_039097592.2 → XP_038953520.1  carboxylesterase 4A isoform X2

      Conserved Domains (1) summary
      pfam00135
      Location:10 → 531
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version

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